| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4686879 | A | Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 2. | ALA4686880 | B | Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 3. | ALA4686881 | A | Agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay relative to GW3965 | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 4. | ALA4686882 | B | Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assay relative to GW3965 | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 5. | ALA4686883 | U | Selectivity index, ratio of EC50 for agonist activity at human RXRalpha/LXRalpha expressed in HEK293 cells to EC50 for agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 6. | ALA4686884 | B | Displacement of hyodeoxycholicacid-based fluorescent tracer from recombinant human LXRbeta LBD (215 to 461 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins under shaking condition and measured after 30 mins by fluorescence polarization assay | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 7. | ALA4686885 | F | Antiproliferative activity against human U87 cells overexpressing EGFR variant III measured after 7 days by CCK8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 8. | ALA4686898 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4686899 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4686900 | A | Half life in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4686901 | A | AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4686902 | A | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4686903 | A | MRT (infinity) in Sprague-Dawley rat at 10 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4686904 | F | Antitumor activity against human U87 cells overexpressing EGFR variant III xenografted in Balb/c nu/nu mouse assessed as reduction in tumor size at 50 mg/kg/day, ip for 15 days by caliper method | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4686906 | T | Toxicity in Balb/c nu/nu mouse xenografted with human U87 cells overexpressing EGFR variant III assessed as body weight loss at 50 mg/kg/day, ip for 15 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4686907 | A | Effect on serum triglyceride level in Balb/c nu/nu mouse xenografted with human U87 cells overexpressing EGFR variant III at 50 mg/kg/day, ip for 15 days | Mus musculus | 3 | organism-based format | Scientific Literature |
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