# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4686156 | Functional | Antiproliferative activity against human SR cells assessed as reduction in cell growth | Homo sapiens | 39 | ALA4680228 | cell-based format | Scientific Literature | |
2. | ALA4686158 | Binding | Protac activity at VHL/NPM-ALK fusion protein in human SR cells assessed as degradation of ALK | Homo sapiens | 10 | ALA4680228 | cell-based format | Scientific Literature | |
3. | ALA4686159 | Binding | Protac activity at VHL/NPM-ALK fusion protein in human SR cells assessed as degradation of ALK at 100 nM | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
4. | ALA4686162 | Binding | Protac activity at VHL/NPM-ALK fusion protein in human SR cells assessed as degradation of ALK measured after 16 hrs in presence of proteasome inhibitor MG132 | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
5. | ALA4686163 | Binding | Protac activity at VHL/NPM-ALK fusion protein in human SR cells assessed as degradation of ALK measured after 16 hrs in presence of proteasome inhibitor MLN4924 | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
6. | ALA4686164 | Binding | Protac activity at VHL/NPM-ALK fusion protein in human SR cells assessed as reduction in ALK phosphorylation at 10 nM | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
7. | ALA4686165 | Binding | Protac activity at VHL/NPM-ALK fusion protein in human SR cells assessed as reduction in STAT3 phosphorylation at 1 to 500 nM | Homo sapiens | 2 | ALA4680228 | cell-based format | Scientific Literature | |
8. | ALA4686167 | Binding | Protac activity at VHL/IGF1R in human SR cells assessed as induction of IGF1R degradation | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
9. | ALA4686168 | Binding | Protac activity at VHL/FLT3 in human SR cells assessed as induction of FLT3 degradation | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
10. | ALA4686169 | Binding | Protac activity at VHL/ROS1 in human SR cells assessed as induction of ROS1 degradation | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
11. | ALA4686170 | Binding | Protac activity at VHL/Aurora A in human SR cells assessed as induction of Aurora A degradation | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
12. | ALA4686171 | Binding | Protac activity at VHL/UCK2 in human SR cells assessed as induction of UCK2 degradation | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
13. | ALA4686172 | Binding | Protac activity at VHL/GAK in human SR cells assessed as induction of GAK degradation | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
14. | ALA4686173 | Functional | Antiproliferative activity against human NCI-H2228 cells expressing EML4-ALK assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay | Homo sapiens | 3 | ALA4680228 | cell-based format | Scientific Literature | |
15. | ALA4686175 | Binding | Protac activity at VHL/EML4-ALK fusion protein in human NCI-H2228 cells assessed as induction of ALK degradation at 50 to 500 nM | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
16. | ALA4686176 | Binding | Protac activity at VHL/EML4-ALK G1202R mutant fusion protein (unknown origin) expressed in HEK293T cells assessed as inhibition of cell growth | Homo sapiens | 4 | ALA4680228 | cell-based format | Scientific Literature | |
17. | ALA4686177 | Binding | Protac activity at VHL/EML4-ALK G1202R mutant fusion protein (unknown origin) expressed in HEK293T cells assessed as induction of ALK degradation by Western blot analysis | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
18. | ALA4686178 | Binding | Inhibition of EML4-ALK G1202R mutant fusion protein (unknown origin) expressed in HEK293T cells | Homo sapiens | 1 | ALA4680228 | cell-based format | Scientific Literature | |
19. | ALA4686179 | Functional | Antiproliferative activity against human NCI-H69 cells assessed as inhibition of cell proliferation | Homo sapiens | 3 | ALA4680228 | cell-based format | Scientific Literature | |
20. | ALA4686180 | Functional | Antiproliferative activity against human NCI-H1688 cells assessed as inhibition of cell proliferation | Homo sapiens | 3 | ALA4680228 | cell-based format | Scientific Literature |