# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4737685 | B | Inhibition of recombinant human HDAC4 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
2. | ALA4737686 | B | Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 23 | single protein format | Scientific Literature | ||
3. | ALA4737687 | B | Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by fluorescence based assay | Homo sapiens | 23 | single protein format | Scientific Literature | ||
4. | ALA4737688 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as half life at 5 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LCMS analysis | Rattus norvegicus | 8 | microsome format | Scientific Literature | ||
5. | ALA4737690 | P | Solubility of compound in PEG400 in PBS at 10 mg/ml | 3 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4737691 | B | Inhibition of recombinant human HDAC5 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
7. | ALA4737692 | B | Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
8. | ALA4737693 | B | Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by fluorescence based assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
9. | ALA4737694 | B | Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
10. | ALA4737695 | B | Inhibition of Class 1 histone deacetylase in human THP-1 cells using Ac-LGK(Ac)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition and measured after 1 hr by fluorescence based assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
11. | ALA4737696 | B | Inhibition of Class 2a histone deacetylase in human THP-1 cells using Ac-LGK(TFA)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition and measured after 1 hr by fluorescence based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
12. | ALA4737697 | B | Inhibition of Class 1 histone deacetylase in human THP-1 cells assessed as accumulation of Histone H4 acetylation levels at 1 to 10 uM incubated for 3 hrs by western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4737698 | F | Antiinflammatory activity in human monocytes-derived macrophages assessed as inhibition of LPS-induced IL-1alpha secretion at 30 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by homogenous time-resolved fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4737699 | F | Antiinflammatory activity in human monocytes-derived macrophages assessed as inhibition of LPS-induced GM-CSF secretion at 30 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by homogenous time-resolved fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4737700 | F | Antiinflammatory activity in human monocytes-derived macrophages assessed as inhibition of LPS-induced IL-23 secretion at 30 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by homogenous time-resolved fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4737701 | F | Antiinflammatory activity in human monocytes-derived macrophages assessed as inhibition of LPS-induced IL-6 secretion at 30 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by homogenous time-resolved fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4737702 | F | Antiinflammatory activity in human monocytes-derived macrophages assessed as inhibition of LPS-induced CCL2 secretion at 30 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by homogenous time-resolved fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4737703 | F | Antiinflammatory activity in human monocytes-derived macrophages assessed as inhibition of LPS-induced IL-12p40 secretion at 30 uM pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by homogenous time-resolved fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature |