# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4712474 | F | Antiproliferative activity against human MM1.S cells assessed as reduction in cell growth measured after 7 days culturing by CellTiter 96 Aqueous non-radioactive cell proliferation assay | Homo sapiens | 51 | cell-based format | Scientific Literature | ||
2. | ALA4712475 | A | Half-life in human liver microsomes | Homo sapiens | 6 | microsome format | Scientific Literature | ||
3. | ALA4712476 | A | Intrinsic clearance in human liver microsomes measured per gm of protein | Homo sapiens | 6 | microsome format | Scientific Literature | ||
4. | ALA4712477 | A | Intrinsic clearance in human | Homo sapiens | 6 | assay format | Scientific Literature | ||
5. | ALA4712478 | A | Hepatic intrinsic clearance in human | Homo sapiens | 6 | assay format | Scientific Literature | ||
6. | ALA4712479 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining | Homo sapiens | 6 | microsome format | Scientific Literature | ||
7. | ALA4712480 | B | Induction of IKZF1 degradation in human MM1.S cells assessed as reduction in IKZF1 level at 0.02 to 2 uM incubated for 12 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4712481 | B | Induction of IKZF3 degradation in human MM1.S cells assessed as reduction in IKZF3 level at 0.02 to 2 uM incubated for 12 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4712484 | F | Antitumor activity against human MM1.S cells xenografted in CB17-SCID mouse assessed as reduction in tumor weight at 60 mg/kg, po qd for 14 days and measured after 14 days | Homo sapiens | 3 | organism-based format | Scientific Literature | ||
10. | ALA4712485 | F | Antitumor activity against human MM1.S cells xenografted in CB17-SCID mouse assessed as tumor weight at 60 mg/kg, po qd for 14 days and measured after 14 days (Rvb = 1.51 +/-0.43 gms) | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
11. | ALA4712486 | T | Toxicity in CB17-SCID mouse xenografted with human MM1.S cells assessed as body weight at 60 mg/kg, po qd for 14 days measured twice a week for 14 days | Mus musculus | 2 | organism-based format | Scientific Literature |