# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4676461 | B | Binding affinity to human plasma coagulation factor XIIA assessed as compound-adduct formation by measuring change in molecular mass at molar ratio of 1:20 measured after 4 mins by SEC/ESI-TOF mass spectra analysis | Homo sapiens | 3 | ALA4673255 | cell-free format | Scientific Literature | |
2. | ALA4676476 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of MDA-MB-231-induced platelet aggregation at 0.1 to 10 uM by light transmission aggregometry | Homo sapiens | 2 | ALA4673255 | cell-free format | Scientific Literature | |
3. | ALA4676480 | B | Selectivity index, ratio of IC50 for inhibition of human coagulation factor alpha-thrombin using Boc-Val-Pro-Arg-AMC as fluorogenic substrate to IC50 for inhibition of human coagulation factor XIIA using Boc-Gln-Gly-Arg-AMC as fluorogenic substrate incubated for 1 hr by fluorometric assay | Homo sapiens | 5 | ALA4673255 | assay format | Scientific Literature | |
4. | ALA4676485 | B | Inhibition of human coagulation factor alpha-thrombin using Boc-Val-Pro-Arg-AMC as fluorogenic substrate at 2 uM measured at 1 min interval for 1 hr by fluorometric assay relative to control | Homo sapiens | 1 | ALA4673255 | single protein format | Scientific Literature | |
5. | ALA4676487 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 100 uM incubated for 48 hrs by alamar blue assay relative to control | Homo sapiens | 3 | ALA4673255 | cell-based format | Scientific Literature | |
6. | ALA4676488 | A | Cytotoxicity against human CCF-STTG1 cells assessed as reduction in cell viability at 100 uM incubated for 48 hrs by alamar blue assay relative to control | Homo sapiens | 2 | ALA4673255 | cell-based format | Scientific Literature | |
7. | ALA4676489 | B | Inhibition of human coagulation factor alpha thrombin in presence of Boc-Val-Pro-Arg-AMC as fluorogenic substrate at 1 uM measured at 1 min interval for 1 hr by fluorometric assay relative to control | Homo sapiens | 25 | ALA4673255 | single protein format | Scientific Literature | |
8. | ALA4676490 | B | Inhibition of human coagulation factor XIIA in presence of Boc-Gln-Gly-Arg-AMC as fluorogenic substrate at 1 uM measured at 1 min interval for 1 hr by fluorometric assay relative to control | Homo sapiens | 25 | ALA4673255 | single protein format | Scientific Literature | |
9. | ALA4676500 | F | Anticoagulant activity in human blood assessed as increase in activated partial thromboplastin time at 300 uM incubated for 1 min by aPTT reagent based assay relative to control | Homo sapiens | 25 | ALA4673255 | tissue-based format | Scientific Literature | |
10. | ALA4676501 | A | Effect on blood coagulation in human blood assessed as increase in prothrombin time at 300 uM incubated for 3 mins followed by CaCl2 addition by PT reagent based assay relative to control | Homo sapiens | 25 | ALA4673255 | tissue-based format | Scientific Literature | |
11. | ALA4676502 | B | Inhibition of porcine trypsin using Z-Gly-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assay | Sus scrofa | 34 | ALA4673255 | assay format | Scientific Literature | |
12. | ALA4676503 | B | Inhibition of human coagulation factor Xa using Boc-Ile-Glu-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assay | Homo sapiens | 36 | ALA4673255 | single protein format | Scientific Literature | |
13. | ALA4676505 | B | Inhibition of human coagulation factor XIIA using Boc-Gln-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assay | Homo sapiens | 37 | ALA4673255 | single protein format | Scientific Literature |