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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4727603 B Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]-methyl-alpha -D-glucopyranoside accumulation Homo sapiens 12 cell-based format Scientific Literature 2. ALA4727604 B Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]-methyl-alpha -D-glucopyranoside accumulation Homo sapiens 12 cell-based format Scientific Literature 3. ALA4727607 A Stability of compound in human liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH Homo sapiens 11 microsome format Scientific Literature 4. ALA4727609 A Stability of compound in mouse liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH Mus musculus 11 microsome format Scientific Literature 5. ALA4727610 A Stability of compound in rat liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH Rattus norvegicus 11 microsome format Scientific Literature 6. ALA4727611 A Clearance in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 organism-based format Scientific Literature 7. ALA4727612 A Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 organism-based format Scientific Literature 8. ALA4727613 A Half life in Sprague-Dawley rat at 2 mg/kg, iv Rattus norvegicus 4 organism-based format Scientific Literature 9. ALA4727614 A AUC (0 to infinity) in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 3 organism-based format Scientific Literature 10. ALA4727615 A Cmax in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 organism-based format Scientific Literature 11. ALA4727616 A Tmax in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 organism-based format Scientific Literature 12. ALA4727617 A Oral bioavailability in Sprague-Dawley rat at 10 mg/kg Rattus norvegicus 4 organism-based format Scientific Literature 13. ALA4727625 F Hypoglycemic activity in overnight fasted Sprague-Dawley rat assessed as percent reduction in blood glucose AUC at 1 mg/kg, po measured after 4 hrs post glucose challenge by OGTT relative to control Rattus norvegicus 3 organism-based format Scientific Literature 14. ALA4727626 F Hypoglycemic activity in overnight fasted Sprague-Dawley rat assessed as percent reduction in blood glucose AUC at 10 mg/kg, po measured after 4 hrs post glucose challenge by OGTT relative to control Rattus norvegicus 3 organism-based format Scientific Literature 15. ALA4727629 F In vivo inhibition of SGLT1/2 in overnight fasted Sprague-Dawley rat assessed as amount of urinary glucose excretion assessed per 4 hrs at 1 mg/kg, po Rattus norvegicus 2 organism-based format Scientific Literature 16. ALA4727630 F In vivo inhibition of SGLT1/2 in overnight fasted Sprague-Dawley rat assessed as amount of urinary glucose excretion assessed per 4 hrs at 10 mg/kg, po Rattus norvegicus 2 organism-based format Scientific Literature 17. ALA4727631 F In vivo inhibition of SGLT1/2 in overnight fasted po dosed Sprague-Dawley rat assessed as reduction in blood glucose by OGTT Rattus norvegicus 2 organism-based format Scientific Literature