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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4727603 Binding Inhibition of human SGLT1 expressed in CHO cells assessed as reduction in [14C]-methyl-alpha -D-glucopyranoside accumulation Homo sapiens 12 ALA4725317 cell-based format Scientific Literature 2. ALA4727604 Binding Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]-methyl-alpha -D-glucopyranoside accumulation Homo sapiens 12 ALA4725317 cell-based format Scientific Literature 3. ALA4727607 ADME Stability of compound in human liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH Homo sapiens 11 ALA4725317 microsome format Scientific Literature 4. ALA4727609 ADME Stability of compound in mouse liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH Mus musculus 11 ALA4725317 microsome format Scientific Literature 5. ALA4727610 ADME Stability of compound in rat liver microsomes assessed as parent compound remaining at 1 uM measured at 10 mins in presence of NADPH Rattus norvegicus 11 ALA4725317 microsome format Scientific Literature 6. ALA4727611 ADME Clearance in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 ALA4725317 organism-based format Scientific Literature 7. ALA4727612 ADME Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 ALA4725317 organism-based format Scientific Literature 8. ALA4727613 ADME Half life in Sprague-Dawley rat at 2 mg/kg, iv Rattus norvegicus 4 ALA4725317 organism-based format Scientific Literature 9. ALA4727614 ADME AUC (0 to infinity) in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 3 ALA4725317 organism-based format Scientific Literature 10. ALA4727615 ADME Cmax in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 ALA4725317 organism-based format Scientific Literature 11. ALA4727616 ADME Tmax in Sprague-Dawley rat at 2 mg/kg, iv or 10 mg/kg, po Rattus norvegicus 4 ALA4725317 organism-based format Scientific Literature 12. ALA4727617 ADME Oral bioavailability in Sprague-Dawley rat at 10 mg/kg Rattus norvegicus 4 ALA4725317 organism-based format Scientific Literature 13. ALA4727625 Functional Hypoglycemic activity in overnight fasted Sprague-Dawley rat assessed as percent reduction in blood glucose AUC at 1 mg/kg, po measured after 4 hrs post glucose challenge by OGTT relative to control Rattus norvegicus 3 ALA4725317 organism-based format Scientific Literature 14. ALA4727626 Functional Hypoglycemic activity in overnight fasted Sprague-Dawley rat assessed as percent reduction in blood glucose AUC at 10 mg/kg, po measured after 4 hrs post glucose challenge by OGTT relative to control Rattus norvegicus 3 ALA4725317 organism-based format Scientific Literature 15. ALA4727629 Functional In vivo inhibition of SGLT1/2 in overnight fasted Sprague-Dawley rat assessed as amount of urinary glucose excretion assessed per 4 hrs at 1 mg/kg, po Rattus norvegicus 2 ALA4725317 organism-based format Scientific Literature 16. ALA4727630 Functional In vivo inhibition of SGLT1/2 in overnight fasted Sprague-Dawley rat assessed as amount of urinary glucose excretion assessed per 4 hrs at 10 mg/kg, po Rattus norvegicus 2 ALA4725317 organism-based format Scientific Literature 17. ALA4727631 Functional In vivo inhibition of SGLT1/2 in overnight fasted po dosed Sprague-Dawley rat assessed as reduction in blood glucose by OGTT Rattus norvegicus 2 ALA4725317 organism-based format Scientific Literature