# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4713238 | ADME | Permeability of compound across apical to basolateral side in MDCK cells at 10 uM | Canis lupus familiaris | 1 | ALA4706658 | cell-based format | Scientific Literature | |
2. | ALA4713239 | Binding | Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay | Homo sapiens | 53 | ALA4706658 | single protein format | Scientific Literature | |
3. | ALA4713240 | Binding | Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay | Homo sapiens | 43 | ALA4706658 | single protein format | Scientific Literature | |
4. | ALA4713241 | Binding | Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay | Homo sapiens | 42 | ALA4706658 | single protein format | Scientific Literature | |
5. | ALA4713242 | Binding | Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay | Homo sapiens | 41 | ALA4706658 | single protein format | Scientific Literature | |
6. | ALA4713243 | Binding | Selectivity index, ratio of IC50 for recombinant JAK2 (unknown origin) to IC50 for recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate | Homo sapiens | 43 | ALA4706658 | assay format | Scientific Literature | |
7. | ALA4713244 | Binding | Selectivity index, ratio of IC50 for recombinant JAK3 (unknown origin) to IC50 for recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate | Homo sapiens | 42 | ALA4706658 | assay format | Scientific Literature | |
8. | ALA4713245 | Binding | Selectivity index, ratio of IC50 for recombinant TYK2 (unknown origin) to IC50 for recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate | Homo sapiens | 39 | ALA4706658 | assay format | Scientific Literature | |
9. | ALA4713246 | Binding | Inhibition of JAK1 (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay | Homo sapiens | 9 | ALA4706658 | cell-based format | Scientific Literature | |
10. | ALA4713247 | Binding | Inhibition of JAK2 (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay | Homo sapiens | 9 | ALA4706658 | cell-based format | Scientific Literature | |
11. | ALA4713248 | Binding | Inhibition of JAK3 (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay | Homo sapiens | 9 | ALA4706658 | cell-based format | Scientific Literature | |
12. | ALA4713249 | Binding | Inhibition of TYK2 (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay | Homo sapiens | 9 | ALA4706658 | cell-based format | Scientific Literature | |
13. | ALA4713250 | Binding | Selectivity index, ratio of GI50 for inhibition of JAK2 (unknown origin) transfected in mouse BAF3 cells to GI50 for inhibition of JAK1 (unknown origin) transfected in mouse BAF3 cells | Homo sapiens | 9 | ALA4706658 | cell-based format | Scientific Literature | |
14. | ALA4713251 | Binding | Selectivity index, ratio of GI50 for inhibition of JAK3 (unknown origin) transfected in mouse BAF3 cells to GI50 for inhibition of JAK1 (unknown origin) transfected in mouse BAF3 cells | Homo sapiens | 9 | ALA4706658 | cell-based format | Scientific Literature | |
15. | ALA4713252 | Binding | Selectivity index, ratio of GI50 for inhibition of TYK2 (unknown origin) transfected in mouse BAF3 cells to GI50 for inhibition of JAK1 (unknown origin) transfected in mouse BAF3 cells | Homo sapiens | 9 | ALA4706658 | cell-based format | Scientific Literature | |
16. | ALA4713253 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 10 uM measured after 30 mins relative to control | Homo sapiens | 1 | ALA4706658 | microsome format | Scientific Literature | |
17. | ALA4713254 | ADME | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 10 uM measured after 30 mins relative to control | Rattus norvegicus | 1 | ALA4706658 | microsome format | Scientific Literature | |
18. | ALA4713255 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 10 uM measured after 30 mins relative to control | Mus musculus | 1 | ALA4706658 | microsome format | Scientific Literature | |
19. | ALA4713256 | ADME | Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4706658 | single protein format | Scientific Literature | |
20. | ALA4713257 | ADME | Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4706658 | single protein format | Scientific Literature |