# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4714753 | B | Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current at 10 uM in absence of extracellular calcium by whole cell patch-clamp method relative to control | Homo sapiens | 9 | ALA4706728 | cell-based format | Scientific Literature | |
2. | ALA4714754 | B | Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in absence of extracellular calcium by whole cell patch-clamp method | Homo sapiens | 2 | ALA4706728 | cell-based format | Scientific Literature | |
3. | ALA4714755 | B | Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in presence of 2 mM extracellular calcium by whole cell patch-clamp method | Homo sapiens | 2 | ALA4706728 | cell-based format | Scientific Literature | |
4. | ALA4714756 | B | Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of OAG-induced current at 0.001 to 10 uM by whole cell patch-clamp method | Homo sapiens | 2 | ALA4706728 | cell-based format | Scientific Literature | |
5. | ALA4714757 | B | Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced current at 10 uM by whole cell patch-clamp method | Homo sapiens | 1 | ALA4706728 | cell-based format | Scientific Literature | |
6. | ALA4714758 | B | Inhibition of rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced current at 10 uM by whole cell patch-clamp method | Rattus norvegicus | 1 | ALA4706728 | cell-based format | Scientific Literature | |
7. | ALA4714759 | B | Inhibition of rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK101-induced current at 10 uM by whole cell patch-clamp method | Rattus norvegicus | 1 | ALA4706728 | cell-based format | Scientific Literature | |
8. | ALA4714760 | B | Inhibition of mouse TRPC6 expressed in HEK293 cells assessed as inhibition of GSK170-induced current at 10 uM by whole cell patch-clamp method | Mus musculus | 1 | ALA4706728 | cell-based format | Scientific Literature | |
9. | ALA4714761 | B | Inhibition of human TRPC7 expressed in HEK293 cells assessed as inhibition of GSK170-induced current at 10 uM by whole cell patch-clamp method | Homo sapiens | 1 | ALA4706728 | cell-based format | Scientific Literature | |
10. | ALA4714762 | B | Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of methanol-induced current at 10 uM by whole cell patch-clamp method | Homo sapiens | 1 | ALA4706728 | cell-based format | Scientific Literature | |
11. | ALA4714763 | A | Inhibition of STIM/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in thapsigargin-induced Ca2+ influx at 10 uM in presence of Ca2+ by whole cell patch clamp method | Homo sapiens | 2 | ALA4706728 | cell-based format | Scientific Literature | |
12. | ALA4714764 | B | Binding affinity to human His8-MBP-TRPC3b I395V mutant expressed in baculovirus infected Sf9 cells incubated for 1 hr by LC-MS analysis | Homo sapiens | 1 | ALA4706728 | cell-based format | Scientific Literature | |
13. | ALA4714765 | A | Metabolic stability in human liver microsomes assessed as half life at 10 mM measured up to 240 mins in presence of NADPH regeneration system by LC-MS analysis | Homo sapiens | 2 | ALA4706728 | microsome format | Scientific Literature | |
14. | ALA4714766 | A | Metabolic stability in mouse liver microsomes assessed as half life at 10 mM measured up to 240 mins in presence of NADPH regeneration system by LC-MS analysis | Mus musculus | 2 | ALA4706728 | microsome format | Scientific Literature | |
15. | ALA4714767 | A | Metabolic stability in rat liver microsomes assessed as half life at 10 mM measured up to 240 mins in presence of NADPH regeneration system by LC-MS analysis | Rattus norvegicus | 2 | ALA4706728 | microsome format | Scientific Literature | |
16. | ALA4714769 | T | Toxicity in NSG/ICR mouse assessed as body weight loss at 200 mg/kg, ip administered once daily for 5 days | Mus musculus | 2 | ALA4706728 | organism-based format | Scientific Literature | |
17. | ALA4714770 | F | Neuroprotective activity in Sprague-Dawley rat primary hippocampal neurons assessed as reduction in Abeta-induced dendrites damage at 0.25 to 1 uM incubated for 16 hrs by MAP2 staining based assay | Rattus norvegicus | 2 | ALA4706728 | tissue-based format | Scientific Literature | |
18. | ALA4714772 | T | Toxicity in NSG/ICR mouse assessed as survival at 200 mg/kg, ip administered once daily for 5 days | Mus musculus | 2 | ALA4706728 | organism-based format | Scientific Literature |