| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4678371 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response at 10 uM relative to control | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 2. | ALA4678372 | A | Cytotoxicity in HEK293 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 3. | ALA4678373 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 4. | ALA4678374 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in calcium entry AUC at 10 uM relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA4678375 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in peak amplitude of calcium entry at 10 uM relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 6. | ALA4678378 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in slope of calcium entry at 10 uM relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 7. | ALA4678379 | A | Cytotoxicity in HEK293 cells assessed as cell viability at 50 uM after 72 hrs by MTT assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 8. | ALA4678380 | A | Cytotoxicity in HEK293 cells assessed as cell viability at 50 uM after 72 hrs in presence of excess uridine by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 9. | ALA4678386 | A | Drug metabolism in mouse liver microsomes assessed as O-demethylation by high-resolution mass spectrometry | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 10. | ALA4678387 | A | Drug metabolism in mouse liver microsomes assessed as oxidation by high-resolution mass spectrometry | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 11. | ALA4678388 | A | Drug metabolism in mouse liver microsomes assessed as hydroxylation by high-resolution mass spectrometry | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 12. | ALA4678390 | A | Drug metabolism in mouse liver microsomes assessed as acyl glucuronide metabolite formation in presence of UDPGA by high-resolution mass spectrometry | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4678391 | A | Drug metabolism in mouse liver microsomes assessed as glutathione adduct formation by high-resolution mass spectrometry | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4678392 | A | Half life in C57BL/6 mouse at 7 mg/kg, iv dosed as single administration measured up to 24 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4678393 | A | Clearance in C57BL/6 mouse at 7 mg/kg, iv dosed as single administration measured up to 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4678394 | A | Volume of distribution in C57BL/6 mouse at 7 mg/kg, iv dosed as single administration measured up to 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4678395 | A | Cmax in C57BL/6 mouse at 7 mg/kg, iv dosed as single administration measured up to 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4678396 | F | Anti pancreatitis activity in C57BL/6 mouse model of cerulein-induced acute pancreatitis assessed as amelioration of histological scores at 10 mg/kg, ip administered 30 and 150 mins after the first cerulein injection measured 5 hrs after first cerulein injection by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4678397 | F | Anti pancreatitis activity in C57BL/6 mouse model of cerulein-induced acute pancreatitis assessed as reduction of inflammation and edema at 10 mg/kg, ip administered 30 and 150 mins after the first cerulein injection measured 5 hrs after first cerulein injection by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4678398 | A | Cytotoxicity in HEK293 cells assessed as cell viability up to 60 uM after 72 hrs in presence of excess uridine by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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