# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4717569 | Binding | Inhibition of human SERT expressed in CHO-K1 cells assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 20 mins by Microscintillation counting analysis | Homo sapiens | 14 | ALA4715727 | cell-based format | Scientific Literature | |
2. | ALA4717570 | Binding | Inhibition of human NET expressed in CHO-K1 cells assessed as inhibition of [3H]-norepinephrine reuptake measured after 45 mins by Microscintillation counting analysis | Homo sapiens | 14 | ALA4715727 | cell-based format | Scientific Literature | |
3. | ALA4717571 | Binding | Inhibition of human DAT expressed in CHO-K1 cells assessed as inhibition of [3H]-dopamine reuptake measured after 60 mins by Microscintillation counting analysis | Homo sapiens | 14 | ALA4715727 | cell-based format | Scientific Literature | |
4. | ALA4717572 | ADME | Permeability coefficient of the compound at 10 uM at pH 7.4 measured after 3 hrs by PAMPA based LC/MS/MS analysis | 7 | ALA4715727 | assay format | Scientific Literature | ||
5. | ALA4717573 | ADME | Substrate activity at human MDR1 expressed in LLC-PK1 cells assessed as efflux ratio of permeability from basolateral to apical side over apical to basolateral side at 10 uM measured after 2 hrs by LC/MS/MS analysis | Homo sapiens | 14 | ALA4715727 | cell-based format | Scientific Literature | |
6. | ALA4717574 | ADME | Inhibition of CYP2D6 (unknown origin) expressed in insect cells assessed as reduction in 1'-hydroxybufuralol formation using bufuralol as substrate at 10 uM incubated for 60 mins by LC/MS/MS analysis | Homo sapiens | 14 | ALA4715727 | cell-based format | Scientific Literature |