# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4716830 | B | Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-Glo luciferase assay | Homo sapiens | 18 | ALA4715698 | cell-based format | Scientific Literature | |
2. | ALA4716832 | B | Inhibition of Tel fused InsR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-Glo luciferase assay | Homo sapiens | 18 | ALA4715698 | cell-based format | Scientific Literature | |
3. | ALA4716833 | A | Antiproliferative activity against wild type mouse BaF3 cells assessed as reduction in cell growth incubated for 2 to 3 days by Bright-Glo luciferase assay | Mus musculus | 18 | ALA4715698 | cell-based format | Scientific Literature | |
4. | ALA4716834 | B | Inhibition of ALK (unknown origin) | Homo sapiens | 9 | ALA4715698 | single protein format | Scientific Literature | |
5. | ALA4716862 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 4 | ALA4715698 | microsome format | Scientific Literature | |
6. | ALA4716863 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance | Rattus norvegicus | 4 | ALA4715698 | microsome format | Scientific Literature | |
7. | ALA4716864 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 4 | ALA4715698 | microsome format | Scientific Literature | |
8. | ALA4716865 | A | Inhibition of CYP3A4 (unknown origin) using midazolam as substrate | Homo sapiens | 4 | ALA4715698 | single protein format | Scientific Literature | |
9. | ALA4716866 | P | Solubility in DMSO at pH 6.8 by high-throughput solubility assay | 4 | ALA4715698 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4716867 | A | Permeability of compound by PAMPA assay | 4 | ALA4715698 | assay format | Scientific Literature | ||
11. | ALA4716868 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 4 | ALA4715698 | cell-based format | Scientific Literature | |
12. | ALA4716869 | A | Permeability across basolateral to apical side in human Caco2 cells | Homo sapiens | 3 | ALA4715698 | cell-based format | Scientific Literature | |
13. | ALA4716871 | B | Inhibition of human ERG by dofetilide binding assay | Homo sapiens | 4 | ALA4715698 | single protein format | Scientific Literature | |
14. | ALA4716872 | A | Clearance in mouse at 5 mg/kg, iv | Mus musculus | 3 | ALA4715698 | organism-based format | Scientific Literature | |
15. | ALA4716873 | A | Volume of distribution at steady state in mouse at 5 mg/kg, iv | Mus musculus | 3 | ALA4715698 | organism-based format | Scientific Literature | |
16. | ALA4716874 | A | Cmax in mouse at 20 mg/kg, po | Mus musculus | 3 | ALA4715698 | organism-based format | Scientific Literature | |
17. | ALA4716875 | A | AUC in mouse at 20 mg/kg, po | Mus musculus | 3 | ALA4715698 | organism-based format | Scientific Literature | |
18. | ALA4716876 | A | Oral bioavailability in mouse at 20 mg/kg | Mus musculus | 3 | ALA4715698 | organism-based format | Scientific Literature | |
19. | ALA4716877 | A | Clearance in rat at 3 mg/kg, iv | Rattus norvegicus | 2 | ALA4715698 | organism-based format | Scientific Literature | |
20. | ALA4716878 | A | Volume of distribution at steady state in rat at 3 mg/kg, iv | Rattus norvegicus | 2 | ALA4715698 | organism-based format | Scientific Literature |