# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4681809 | Binding | Inhibition of protein interaction between beta-catenin (unknown origin)/BCL9 in human SW480 cells transfected with beta-catenin assessed as reduction in Wnt/beta-catenin transactivation incubated for 24 hrs by Wnt-responsive FOP-Flash luciferase reporter assay | Homo sapiens | 13 | ALA4680104 | cell-based format | Scientific Literature | |
2. | ALA4681810 | Binding | Selectivity index, ratio of Ki for inhibition of protein interaction between beta-catenin (unknown origin)/human E-cadherin to Ki for inhibition of protein interaction between beta-catenin (unknown origin)/human BCL9 | Homo sapiens | 2 | ALA4680104 | assay format | Scientific Literature | |
3. | ALA4681811 | Binding | Inhibition of protein interaction between C-terminal 6x-histidine tagged full-length beta-catenin (1 to 781 residues) (unknown origin)/N-terminal biotinylated human BCL9 ( 350 to 375 residues) incubated for 1 hr by Alpha-screen competitive inhibition assay | Homo sapiens | 32 | ALA4680104 | protein complex format | Scientific Literature | |
4. | ALA4681814 | Binding | Inhibition of protein interaction between C-terminal 6x-histidine tagged full-length beta-catenin (1 to 781 residues) (unknown origin)/N-terminal biotinylated human E-cadherin (824 to 877 residues) incubated for 1 hr by Alpha-screen competitive inhibition assay | Homo sapiens | 2 | ALA4680104 | assay format | Scientific Literature | |
5. | ALA4681815 | Binding | Inhibition of protein interaction between beta-catenin D145A mutant (unknown origin)/N-terminal biotinylated human BCL9 ( 350 to 375 residues) incubated for 1 hr by Alpha-screen competitive inhibition assay | Homo sapiens | 3 | ALA4680104 | assay format | Scientific Literature | |
6. | ALA4681816 | Binding | Inhibition of protein interaction between beta-catenin D145A/E155A mutant (unknown origin)/N-terminal biotinylated human BCL9 ( 350 to 375 residues) incubated for 1 hr by Alpha-screen competitive inhibition assay | Homo sapiens | 3 | ALA4680104 | assay format | Scientific Literature | |
7. | ALA4681817 | Binding | Inhibition of protein interaction between beta-catenin K181A mutant (unknown origin)/N-terminal biotinylated human BCL9 ( 350 to 375 residues) incubated for 1 hr by Alpha-screen competitive inhibition assay | Homo sapiens | 3 | ALA4680104 | assay format | Scientific Literature | |
8. | ALA4681818 | Functional | Cytotoxicity in human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 32 | ALA4680104 | cell-based format | Scientific Literature | |
9. | ALA4681819 | Functional | Cytotoxicity in human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 19 | ALA4680104 | cell-based format | Scientific Literature | |
10. | ALA4681820 | Functional | Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 14 | ALA4680104 | cell-based format | Scientific Literature | |
11. | ALA4681821 | Functional | Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 16 | ALA4680104 | cell-based format | Scientific Literature | |
12. | ALA4681822 | Binding | Inhibition of protein interaction between beta-catenin (unknown origin)/BCL9 in HEK293 cells transfected with beta-catenin assessed as reduction in Wnt/beta-catenin transactivation incubated for 24 hrs by Wnt-responsive TOP-Flash luciferase reporter assay | Homo sapiens | 13 | ALA4680104 | cell-based format | Scientific Literature | |
13. | ALA4681823 | Binding | Inhibition of protein interaction between beta-catenin (unknown origin)/BCL9 in human SW480 cells transfected with beta-catenin assessed as reduction in Wnt/beta-catenin transactivation incubated for 24 hrs by Wnt-responsive TOP-Flash luciferase reporter assay | Homo sapiens | 17 | ALA4680104 | cell-based format | Scientific Literature | |
14. | ALA4681825 | ADME | Cytotoxic activity in human SW480 cells at 800 uM incubated for 4 hrs by LDH release assay | Homo sapiens | 13 | ALA4680104 | cell-based format | Scientific Literature | |
15. | ALA4681826 | Binding | Inhibition of protein interaction between beta-catenin (unknown origin)/BCL9 in HEK293 cells transfected with beta-catenin assessed as reduction in Wnt/beta-catenin transactivation incubated for 24 hrs by Wnt-responsive FOP-Flash luciferase reporter assay | Homo sapiens | 13 | ALA4680104 | cell-based format | Scientific Literature | |
16. | ALA4681827 | Binding | Inhibition of protein interaction between beta-catenin /BCL9 in human SW480 cells assessed as reduction in Wnt target genes by measuring Axin2 mRNA expression incubated for 24 hrs by qPCR analysis | Homo sapiens | 3 | ALA4680104 | cell-based format | Scientific Literature | |
17. | ALA4681828 | Binding | Inhibition of protein interaction between beta-catenin /BCL9 in human SW480 cells assessed as reduction in Wnt target genes by measuring cyclin D1 mRNA expression incubated for 24 hrs by qPCR analysis | Homo sapiens | 3 | ALA4680104 | cell-based format | Scientific Literature | |
18. | ALA4681829 | Binding | Inhibition of protein interaction between beta-catenin /BCL9 in human SW480 cells assessed as reduction in Wnt target genes by measuring LEF1 mRNA expression incubated for 24 hrs by qPCR analysis | Homo sapiens | 3 | ALA4680104 | cell-based format | Scientific Literature | |
19. | ALA4681831 | Binding | Inhibition of protein interaction between beta-catenin /BCL9 in human SW480 cells assessed as reduction in Wnt target genes by measuring c-Myc protein expression at 25 to 100 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4680104 | cell-based format | Scientific Literature | |
20. | ALA4681832 | Binding | Inhibition of protein interaction between beta-catenin /BCL9 in human SW480 cells assessed as reduction in active form of beta-catenin expression incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4680104 | cell-based format | Scientific Literature |