# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4687433 | B | Inhibition of recombinant human N-terminal His6-tagged full length USP7 expressed in baculovirus infected Sf21 cells using monoubiquitinated ubiquitin-rhodamine as substrate incubated for 30 mins followed by Ub-Rho addition and measured after 2 hrs by spectrophotometry | Homo sapiens | 45 | ALA4680269 | cell-based format | Scientific Literature | |
2. | ALA4687436 | B | Inhibition of UCH-L1 (unknown origin) at 20 uM | Homo sapiens | 2 | ALA4680269 | single protein format | Scientific Literature | |
3. | ALA4687437 | B | Inhibition of UCH-L5 (unknown origin) at 20 uM | Homo sapiens | 2 | ALA4680269 | single protein format | Scientific Literature | |
4. | ALA4687438 | B | Inhibition of USP11 (unknown origin) at 20 uM | Homo sapiens | 2 | ALA4680269 | single protein format | Scientific Literature | |
5. | ALA4687439 | B | Inhibition of USP2 (unknown origin) at 20 uM | Homo sapiens | 2 | ALA4680269 | single protein format | Scientific Literature | |
6. | ALA4687440 | B | Inhibition of USP25 (unknown origin) at 20 uM | Homo sapiens | 2 | ALA4680269 | single protein format | Scientific Literature | |
7. | ALA4687441 | B | Inhibition of USP28 (unknown origin) at 20 uM | Homo sapiens | 2 | ALA4680269 | single protein format | Scientific Literature | |
8. | ALA4687442 | B | Binding affinity to USP7 (208 to 560 residues) (unknown origin) assessed as dissociation constant by biolayer interferometry | Homo sapiens | 2 | ALA4680269 | single protein format | Scientific Literature | |
9. | ALA4687443 | F | Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 6 days by cell-titer glo assay | Homo sapiens | 2 | ALA4680269 | cell-based format | Scientific Literature | |
10. | ALA4687444 | F | Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability incubated for 3 days by cell-titer glo assay | Homo sapiens | 2 | ALA4680269 | cell-based format | Scientific Literature | |
11. | ALA4687445 | F | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 3 days by cell-titer glo assay | Homo sapiens | 2 | ALA4680269 | cell-based format | Scientific Literature | |
12. | ALA4687446 | F | Antiproliferative activity against human NB-4 cells assessed as reduction in cell viability incubated for 3 days by cell-titer glo assay | Homo sapiens | 2 | ALA4680269 | cell-based format | Scientific Literature | |
13. | ALA4687447 | F | Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 3 days by cell-titer glo assay | Homo sapiens | 2 | ALA4680269 | cell-based format | Scientific Literature | |
14. | ALA4687448 | F | Antiproliferative activity against human HuH-7 cells assessed as reduction in cell viability incubated for 3 days by cell-titer glo assay | Homo sapiens | 2 | ALA4680269 | cell-based format | Scientific Literature | |
15. | ALA4687449 | F | Induction of apoptosis in human RS4-11 cells assessed as viable cells at 1 uM incubated for 24 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 92.2 %) | Homo sapiens | 1 | ALA4680269 | cell-based format | Scientific Literature | |
16. | ALA4687450 | F | Induction of apoptosis in human RS4-11 cells assessed as early apoptotic cells at 1 uM incubated for 24 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 1.12 %) | Homo sapiens | 1 | ALA4680269 | cell-based format | Scientific Literature | |
17. | ALA4687451 | F | Induction of apoptosis in human RS4-11 cells assessed as late apoptotic cells at 1 uM incubated for 24 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 6.11 %) | Homo sapiens | 1 | ALA4680269 | cell-based format | Scientific Literature | |
18. | ALA4687452 | F | Induction of apoptosis in human RS4-11 cells assessed as necrotic cells at 1 uM incubated for 24 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 0.53 %) | Homo sapiens | 1 | ALA4680269 | cell-based format | Scientific Literature | |
19. | ALA4687453 | F | Induction of apoptosis in human RS4-11 cells assessed as viable cells at 1 uM incubated for 48 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 92.2 %) | Homo sapiens | 1 | ALA4680269 | cell-based format | Scientific Literature | |
20. | ALA4687454 | F | Induction of apoptosis in human RS4-11 cells assessed as early apoptotic cells at 1 uM incubated for 48 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 1.12 %) | Homo sapiens | 1 | ALA4680269 | cell-based format | Scientific Literature |