# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4714232 | B | Inhibition of recombinant human N-terminal His6-tagged ACC1 expressed in baculovirus infected Sf9 insect cells using acetyl-CoA as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Homo sapiens | 15 | ALA4706693 | cell-based format | Scientific Literature | |
2. | ALA4714233 | B | Inhibition of recombinant human N-terminal His6-tagged ACC2 expressed in baculovirus infected Sf9 insect cells using acetyl-CoA as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins Rapidfire-Mass spectrometry | Homo sapiens | 15 | ALA4706693 | cell-based format | Scientific Literature | |
3. | ALA4714237 | F | Inhibition of fatty acid synthesis in human HCT-116 cells assessed as reduction in [14C] acetic acid uptake preincubated for 60 mins followed by [14C]acetic acid addition and measured after 2 hrs by topcount scintillation counting method | Homo sapiens | 9 | ALA4706693 | cell-based format | Scientific Literature | |
4. | ALA4714238 | P | Solubility of compound in pH 6.8 buffer | 5 | ALA4706693 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4714239 | P | Lipophilicity, log D of compound | 2 | ALA4706693 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4714240 | P | Solubility of compound in pH 1.2 buffer | 2 | ALA4706693 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4714241 | A | Permeability of compound at pH 7.4 by PAMPA | 2 | ALA4706693 | assay format | Scientific Literature | ||
8. | ALA4714242 | A | Permeability of compound at pH 5 by PAMPA | 2 | ALA4706693 | assay format | Scientific Literature | ||
9. | ALA4714243 | A | Metabolic stability in human liver microsomes | Homo sapiens | 2 | ALA4706693 | microsome format | Scientific Literature | |
10. | ALA4714244 | A | Metabolic stability in mouse liver microsomes | Mus musculus | 2 | ALA4706693 | microsome format | Scientific Literature | |
11. | ALA4714245 | A | Inhibition of CYP2C8 (unknown origin) relative to control | Homo sapiens | 2 | ALA4706693 | single protein format | Scientific Literature | |
12. | ALA4714246 | A | Inhibition of CYP2C9 (unknown origin) relative to control | Homo sapiens | 2 | ALA4706693 | single protein format | Scientific Literature | |
13. | ALA4714247 | A | AUC (0 to 8 hrs) in ICR mouse at 0.1 mg/kg, iv or 1 mg/kg, po | Mus musculus | 2 | ALA4706693 | organism-based format | Scientific Literature | |
14. | ALA4714248 | A | Oral bioavailability in ICR mouse at 1 mg/kg | Mus musculus | 2 | ALA4706693 | organism-based format | Scientific Literature | |
15. | ALA4714249 | F | Inhibition of fatty acid synthesis in human HCT-116 cells xenografted BALB/cA Jc1 nu/nu mouse assessed as reduction in malonyl-CoA concentration in tumor at 100 mg/kg, po administered as single dose measured after 2 to 16 hrs by RPLC-MS/MS analysis | Mus musculus | 1 | ALA4706693 | organism-based format | Scientific Literature |