# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4666131 | B | Inhibition of recombinant human CDK5/p25 expressed in bacteria assessed as residual activity at 10 uM using histone H1 as substrate in presence of [gamma-33P]ATP relative to control | Homo sapiens | 28 | assay format | Scientific Literature | ||
2. | ALA4666132 | B | Inhibition of recombinant human CDK5/p25 expressed in bacteria assessed as residual activity at 1 uM using histone H1 as substrate in presence of [gamma-33P]ATP relative to control | Homo sapiens | 28 | assay format | Scientific Literature | ||
3. | ALA4666133 | B | Inhibition of recombinant mouse CLK1 expressed in bacteria assessed as residual activity at 10 uM using GRSRSRSRSRSR as substrate in presence of [gamma-33P]ATP relative to control | Mus musculus | 28 | assay format | Scientific Literature | ||
4. | ALA4666134 | B | Inhibition of recombinant mouse CLK1 expressed in bacteria assessed as residual activity at 1 uM using GRSRSRSRSRSR as substrate in presence of [gamma-33P]ATP relative to control | Mus musculus | 28 | assay format | Scientific Literature | ||
5. | ALA4666135 | B | Inhibition of rat DYRK1A kinase domain (1 to 499 residues) expressed in bacteria assessed as residual activity at 10 uM using KKISGRLSPIMTEQ as substrate in presence of [gamma-33P]ATP relative to control | Rattus norvegicus | 28 | assay format | Scientific Literature | ||
6. | ALA4666136 | B | Inhibition of rat DYRK1A kinase domain (1 to 499 residues) expressed in bacteria assessed as residual activity at 1 uM using KKISGRLSPIMTEQ as substrate in presence of [gamma-33P]ATP relative to control | Rattus norvegicus | 28 | assay format | Scientific Literature | ||
7. | ALA4666137 | B | Inhibition of porcine brain CK1delta/epsilon assessed as residual activity at 10 uM using RRKHAAIGSpAYSITA as substrate in presence of [gamma-33P]ATP relative to control | Sus scrofa domesticus | 28 | tissue-based format | Scientific Literature | ||
8. | ALA4666138 | B | Inhibition of porcine brain CK1delta/epsilon assessed as residual activity at 1 uM using RRKHAAIGSpAYSITA as substrate in presence of [gamma-33P]ATP relative to control | Sus scrofa domesticus | 28 | tissue-based format | Scientific Literature | ||
9. | ALA4666139 | B | Inhibition of porcine brain GSK-3alpha/beta assessed as residual activity at 10 uM using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate in presence of [gamma-33P]ATP relative to control | Sus scrofa domesticus | 28 | tissue-based format | Scientific Literature | ||
10. | ALA4666140 | B | Inhibition of porcine brain GSK-3alpha/beta assessed as residual activity at 1 uM using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate in presence of [gamma-33P]ATP relative to control | Sus scrofa domesticus | 28 | tissue-based format | Scientific Literature | ||
11. | ALA4666141 | B | Inhibition of recombinant mouse CLK1 expressed in bacteria using GRSRSRSRSRSR as substrate in presence of [gamma-33P]ATP | Mus musculus | 10 | assay format | Scientific Literature | ||
12. | ALA4666142 | B | Inhibition of rat DYRK1A kinase domain (1 to 499 residues) expressed in bacteria using KKISGRLSPIMTEQ as substrate in presence of [gamma-33P]ATP | Rattus norvegicus | 6 | assay format | Scientific Literature | ||
13. | ALA4666145 | B | Selectivity index, ratio of IC50 for recombinant mouse CLK1 expressed in bacteria to IC50 for rat DYRK1A kinase domain (1 to 499 residues) expressed in bacteria | 2 | assay format | Scientific Literature | |||
14. | ALA4666146 | A | Antiproliferative activity against hTERT-RPE1 cells assessed as cell viability at 2 uM after 48 hrs by CellTiter96 AQueous assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
15. | ALA4666147 | F | Antiproliferative activity against human HCT116 cells assessed as cell viability at 2 uM after 48 hrs by CellTiter96 AQueous assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
16. | ALA4666148 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability at 2 uM after 48 hrs by CellTiter96 AQueous assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
17. | ALA4666149 | F | Antiproliferative activity against human SH-SY5Y cells assessed as cell viability at 2 uM after 48 hrs by CellTiter96 AQueous assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
18. | ALA4666150 | F | Antiproliferative activity against human U2OS cells assessed as cell viability at 2 uM after 48 hrs by CellTiter96 AQueous assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature |