# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4673815 | B | Binding affinity to MTH1 in human K562 cells assessed as thermal stabilization preincubated for 30 mins followed by heating at 52 degree C for 3 mins by CETSA-based Western blot analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
2. | ALA4673817 | B | Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
3. | ALA4673819 | A | Half-life in Wistar Han rat at 3 micromol/kg, po or 1.5 micromol/kg. iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
4. | ALA4673821 | A | Volume of distribution at steady state in Wistar Han rat at 3 micromol/kg, po or 1.5 micromol/kg. iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
5. | ALA4673822 | A | Clearance in Wistar Han rat at 3 micromol/kg, po or 1.5 micromol/kg. iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
6. | ALA4673823 | A | Oral bioavailability in Wistar Han rat at 3 micromol/kg | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
7. | ALA4673825 | A | Permeability of compound from apical to basolateral side in human Caco2 cells at pH 7.4 | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
8. | ALA4673826 | A | Plasma protein binding in human assessed as fraction unbound | Homo sapiens | 21 | cell-free format | Scientific Literature | ||
9. | ALA4673827 | A | Intrinsic clearance in human liver microsome | Homo sapiens | 21 | microsome format | Scientific Literature | ||
10. | ALA4673828 | P | Lipophilicity, log D of compound at pH 7.4 | 23 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA4673829 | B | Agonist activity at TLR7 in human PBMC assessed as induction of IN-12 stimulation | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
12. | ALA4673830 | B | Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins by PPiLight detection reagent based luminescence assay | Homo sapiens | 26 | single protein format | Scientific Literature |