# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4682086 | B | Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
2. | ALA4682087 | B | Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-current amplitude in response to the depolarizing pulse by whole cell patch clamp assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
3. | ALA4682088 | B | Selectivity index, ratio of IC50 for inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes to IC50 for activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-current amplitude | 4 | cell-based format | Scientific Literature | |||
4. | ALA4682091 | F | Analgesic activity in Sprague-Dawley rat model of PNL injury-induced neuropathic pain assessed as pain threshold elevation percentage at 15 nmol/kg, IM administered as single dose measured after 2 to 2.5 hrs post dose | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
5. | ALA4682094 | B | Inhibition of rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay | Rattus norvegicus | 8 | cell-based format | Scientific Literature | ||
6. | ALA4682095 | B | Inhibition of rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 uM at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
7. | ALA4682096 | B | Inhibition of rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 uM at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
8. | ALA4682097 | B | Inhibition of rat alpha2beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 uM at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
9. | ALA4682098 | B | Inhibition of rat alpha2beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 uM at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
10. | ALA4682099 | B | Inhibition of rat alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 uM at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
11. | ALA4682100 | B | Inhibition of rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 uM at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
12. | ALA4682101 | B | Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated Ba2+ peak-current amplitude in response to depolarizing pulse in presence of 1 uM GABAB receptor antagonist CGP55845 by whole cell patch clamp assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4682102 | B | Inhibition of TTX-resistant sodium channel in Sprague-Dawley rat DRG neuron at 10 uM at 10 mV holding potential by whole cell patch clamp technique | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
14. | ALA4682103 | B | Inhibition of TTX-sensitive sodium channel in Sprague-Dawley rat DRG neuron at 10 uM at -10 mV holding potential by whole cell patch clamp technique | Rattus norvegicus | 3 | tissue-based format | Scientific Literature | ||
15. | ALA4682104 | B | Selectivity index, ratio of IC50 for inhibition of rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes to IC50 for activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak Ba2+ current amplitude | 5 | cell-based format | Scientific Literature | |||
16. | ALA4682105 | B | Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-current amplitude in response to depolarizing pulse at 1 nM by whole cell patch clamp assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
17. | ALA4682107 | B | Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-current amplitude in response to depolarizing pulse at 1 nM in presence of with 10 uM baclofen by whole cell patch clamp assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4682108 | B | Inhibition of rat CaV2.2 channel expressed in HEK293T cells assessed as reduction in CaV2.2-mediated peak-current amplitude in response to depolarizing pulse at 10 uM by whole cell patch clamp assay relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature |