# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4672668 | B | Selectivity index, ratio of IC50 for inhibition of purified human plasma trypsin to IC50 for inhibition of purified human thrombin | Homo sapiens | 1 | ALA4665889 | protein format | Scientific Literature | |
2. | ALA4672669 | B | Inhibition of purified human plasma thrombin using Boc-Asp(OBzl)-Pro-Arg-AMC substrate incubated for 30 mins by fluorescence based assay | Homo sapiens | 56 | ALA4665889 | single protein format | Scientific Literature | |
3. | ALA4672670 | A | Permeability from apical to basolateral side in human Caco2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 46 | ALA4665889 | cell-based format | Scientific Literature | |
4. | ALA4672671 | A | Clearance in Wistar rat hepatocytes at 1 uM incubated up to 90 mins by LC-MS/MS analysis | Rattus norvegicus | 45 | ALA4665889 | cell-based format | Scientific Literature | |
5. | ALA4672672 | A | Activation of human PXR expressed in human HepG2 cells | Homo sapiens | 45 | ALA4665889 | cell-based format | Scientific Literature | |
6. | ALA4672674 | F | Anticoagulation activity in human plasma assessed as drug level causing doubling of prothrombin time incubated for 3 mins | Homo sapiens | 2 | ALA4665889 | cell-free format | Scientific Literature | |
7. | ALA4672676 | A | MRT in Wistar Hannover rat at 0.3 to 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4665889 | organism-based format | Scientific Literature | |
8. | ALA4672677 | A | AUC/dose in Wistar Hannover rat at 0.3 to 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4665889 | organism-based format | Scientific Literature | |
9. | ALA4672678 | A | Blood clearance in Wistar Hannover rat at 0.3 to 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 11 | ALA4665889 | organism-based format | Scientific Literature | |
10. | ALA4672679 | A | Ratio of drug level in blood to plasma in Wistar Hannover rat at 0.3 to 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4665889 | organism-based format | Scientific Literature | |
11. | ALA4672680 | A | Volume of distribution at steady state in Wistar Hannover rat at 0.3 to 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4665889 | organism-based format | Scientific Literature | |
12. | ALA4672681 | A | Half life in Wistar Hannover rat at 0.3 to 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4665889 | organism-based format | Scientific Literature | |
13. | ALA4672682 | A | Oral bioavailability in Wistar Hannover rat at 1 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 10 | ALA4665889 | organism-based format | Scientific Literature | |
14. | ALA4672683 | A | Activation of human PXR human hepatocytes assessed as induction of CYP3A4 mRNA expression incubated for 48 hrs by qPCR analysis | Homo sapiens | 10 | ALA4665889 | tissue-based format | Scientific Literature | |
15. | ALA4672684 | A | Protein binding in rat plasma | Rattus norvegicus | 1 | ALA4665889 | cell-free format | Scientific Literature | |
16. | ALA4672685 | A | Protein binding in human plasma | Homo sapiens | 1 | ALA4665889 | cell-free format | Scientific Literature | |
17. | ALA4672686 | B | Inhibition of purified human plasma trypsin up to 20 uM using Boc-Ile-Glu-Gly-Arg-AMC substrate incubated for 30 mins by fluorescence based assay | Homo sapiens | 1 | ALA4665889 | protein format | Scientific Literature | |
18. | ALA4672687 | B | Inhibition of purified human plasma plasmin up to 20 uM using MeOSuc-Ala-Phe-Lys-AMC substrate incubated for 30 mins by fluorescence based assay | Homo sapiens | 1 | ALA4665889 | single protein format | Scientific Literature | |
19. | ALA4672688 | B | Inhibition of purified human plasma tPA up to 20 uM using CH3SO2-DPhe-Gly-Arg-AMC substrate incubated for 30 mins by fluorescence based assay | Homo sapiens | 1 | ALA4665889 | single protein format | Scientific Literature | |
20. | ALA4672689 | B | Inhibition of purified human plasma factor-7a up to 20 uM incubated for 30 mins by fluorescence based based coupled protease reaction assay | Homo sapiens | 1 | ALA4665889 | single protein format | Scientific Literature |