# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4672559 | Binding | Inhibition of PKC(pan)/beta II phosphorylation at S660 residue in human BXPC-3 cells at 1 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4665887 | cell-based format | Scientific Literature | |
2. | ALA4672561 | Toxicity | Toxicity in BALB/c mouse model of patient-derived xenograft implanted with patient-derived pancreatic cancer cells assessed as effect on normal anatomical structures of heart at 6 mg/kg, iv dosed once every 2 days for 18 days relative to control | Mus musculus | 1 | ALA4665887 | organism-based format | Scientific Literature | |
3. | ALA4672562 | Binding | Inhibition of PKCtheta (unknown origin) at 2.5 ug/ml by HTRF assay relative to control | Homo sapiens | 67 | ALA4665887 | single protein format | Scientific Literature | |
4. | ALA4672563 | Binding | Inhibition of PKCtheta (unknown origin) by HTRF assay | Homo sapiens | 67 | ALA4665887 | single protein format | Scientific Literature | |
5. | ALA4672564 | Functional | Antitumor activity against human BXPC-3 cells xenografted in nude BALB/c mouse assessed as inhibition of tumor growth at 6 mg/kg, iv QD for 18 days relative to control | Homo sapiens | 1 | ALA4665887 | organism-based format | Scientific Literature | |
6. | ALA4672566 | Toxicity | Toxicity in nude BALB/c mouse xenografted with human BXPC-3 cells assessed as effect on body weight level at 6 mg/kg, iv QD for 18 days relative to control | Mus musculus | 1 | ALA4665887 | organism-based format | Scientific Literature | |
7. | ALA4672568 | Functional | Induction of apoptosis in human BXPC-3 cells incubated for 24 hrs by PI and annexin V-FITC staining based flow cytometry | Homo sapiens | 1 | ALA4665887 | cell-based format | Scientific Literature | |
8. | ALA4672569 | Functional | Induction of apoptosis in human BXPC-3 cells assessed as increase in cleaved PARP level at 0.25 uM incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | ALA4665887 | cell-based format | Scientific Literature | |
9. | ALA4672570 | Functional | Induction of apoptosis in human BXPC-3 cells assessed as increase in cleaved caspase-3 level at 0.25 uM incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | ALA4665887 | cell-based format | Scientific Literature | |
10. | ALA4672571 | Functional | Induction of apoptosis in human BXPC-3 cells assessed as increase in cleaved caspase-7 level at 0.25 uM incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | ALA4665887 | cell-based format | Scientific Literature | |
11. | ALA4672572 | Functional | Induction of apoptosis in human BXPC-3 cells assessed as increase in cleaved caspase-9 level at 0.25 uM incubated for 30 mins by Western blot analysis | Homo sapiens | 1 | ALA4665887 | cell-based format | Scientific Literature | |
12. | ALA4672573 | Functional | Cytotoxicity in human BXPC-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
13. | ALA4672574 | Functional | Cytotoxicity in human ASPC1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
14. | ALA4672575 | Functional | Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
15. | ALA4672576 | Functional | Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
16. | ALA4672577 | Functional | Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
17. | ALA4672578 | Functional | Cytotoxicity in human PC-9 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
18. | ALA4672579 | Functional | Cytotoxicity in human RKO cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
19. | ALA4672580 | Functional | Cytotoxicity in human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4665887 | cell-based format | Scientific Literature | |
20. | ALA4672581 | Functional | Induction of apoptosis in human BXPC-3 cells assessed as viable cells level at 0.25 uM incubated for 24 hrs by PI and annexin V-FITC staining based flow cytometry (Rvb = 93.43%) | Homo sapiens | 1 | ALA4665887 | cell-based format | Scientific Literature |