| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4729442 | P | Octanol/buffer partition coefficient, log D of the compound at pH 7.4 by shake-flask method | 23 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA4729444 | B | Inhibition of recombinant human N-terminal GST-tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate measured after 240 mins by mobility shift assay | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 3. | ALA4729445 | B | Inhibition of kinase tracer 236 binding to recombinant human full-length GST-tagged IRAK3 expressed in insect cells by Lanthascreen Eu kinase binding assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 4. | ALA4729447 | B | Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrate measured after 240 mins by mobility shift assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 5. | ALA4729458 | B | Inhibition of CRBN (unknown origin) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 6. | ALA4729459 | B | Protac activity at CRBN/IRAK3 in LPS-induced human THP1 cells assessed as induction of IRAK3 degradation after 16 hrs by Western blot analysis | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 7. | ALA4729490 | B | Protac activity at CRBN/IRAK3 in human THP1 cells assessed as induction of IRAK3 degradation at 0.1 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4729491 | B | Protac activity at CRBN/IRAK3 in human PBMC derived primary macrophages assessed as induction of IRAK3 degradation at 0.3 uM measured after 8 to 32 hrs by Western blot analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 9. | ALA4729492 | B | Protac activity at CRBN/IRAK3 in human PBMC derived primary macrophages assessed as induction of IRAK3 degradation at 0.3 uM preincubated for 8 hrs followed by LPS-stimulation and measured after 8 to 32 hrs by Western blot analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature |
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