| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4689032 | B | Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth at 30 degreeC measured after 24 to 48 hrs | Homo sapiens | 4 | ALA4680333 | assay format | Scientific Literature | |
| 2. | ALA4689033 | B | Inhibition of human SphK2 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth at 30 degreeC measured after 24 to 48 hrs | Homo sapiens | 4 | ALA4680333 | assay format | Scientific Literature | |
| 3. | ALA4689034 | B | Inhibition of recombinant human SphK1 expressed in baculovirus infected Sf9 cells assessed as decrease in [33P]SIP production at 0.1 uM using D-erythro-sphingosine as substrate in presence of [gamma33P]-ATP by scintillation counting method relative to control | Homo sapiens | 30 | ALA4680333 | cell-based format | Scientific Literature | |
| 4. | ALA4689035 | B | Inhibition of recombinant human SphK2 assessed as decrease in [33P]SIP production at 0.3 uM using sphingosine as substrate in presence of [gamma33P]-ATP by scintillation counting method relative to control | Homo sapiens | 30 | ALA4680333 | single protein format | Scientific Literature | |
| 5. | ALA4689036 | B | Inhibition of recombinant human SphK1 expressed in baculovirus infected Sf9 cells assessed as decrease in [33P]SIP production using D-erythro-sphingosine as substrate in presence of [gamma33P]-ATP by scintillation counting method | Homo sapiens | 7 | ALA4680333 | cell-based format | Scientific Literature | |
| 6. | ALA4689037 | B | Inhibition of recombinant human SphK2 assessed as decrease in [33P]SIP production using sphingosine as substrate in presence of [gamma33P]-ATP by scintillation counting method | Homo sapiens | 6 | ALA4680333 | single protein format | Scientific Literature | |
| 7. | ALA4689038 | B | Selectivity ratio of Ki for recombinant human SphK2 assessed as decrease in [33P]SIP production using sphingosine as substrate in presence of [gamma33P]-ATP by scintillation counting method to Ki for recombinant human SphK1 expressed in baculovirus infected Sf9 cells assessed as decrease in [33P]SIP production using D-erythro-sphingosine as substrate in presence of [gamma33P]-ATP by scintillation counting method | Homo sapiens | 2 | ALA4680333 | cell-based format | Scientific Literature | |
| 8. | ALA4689039 | B | Inhibition of SphK1/SphK2 in human U-937 cells assessed as reduction in S1P production measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA4680333 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!