# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4737518 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
2. | ALA4737519 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay relative to relaxin | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
3. | ALA4737521 | P | Aqueous solubility of compound in phosphate buffer at pH 7.4 measured after 24 hrs by UPLC analysis | 13 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4737527 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv measured upto 72 hrs by LC-HRMS analysis | Rattus norvegicus | 13 | organism-based format | Scientific Literature | ||
5. | ALA4737528 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins in presence of 2 % HSA by HTRF assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
6. | ALA4737529 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins in presence of 2 % HSA by HTRF assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
7. | ALA4737530 | B | Selectivity ratio of EC50 for agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells in presence of 2 % HSA to EC50 for agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells in absence of HSA | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
8. | ALA4737531 | A | Bioavailability in Sprague-Dawley rat at 3 mg/kg, sc measured upto 72 hrs by LC-HRMS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
9. | ALA4737537 | A | Stability in human blood assessed as parent compound at 5 uM remaining after 4 hrs | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
10. | ALA4737538 | A | Stability in rat blood assessed as parent compound at 5 uM remaining after 4 hrs | Rattus norvegicus | 2 | tissue-based format | Scientific Literature |