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# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4736493 | Functional | Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
2. | ALA4736494 | Functional | Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
3. | ALA4736495 | Functional | Antiproliferative activity against human M21 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
4. | ALA4736496 | Functional | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay | Homo sapiens | 33 | ALA4732153 | cell-based format | Scientific Literature | |
5. | ALA4736497 | Functional | Cell cycle arrest in human M21 cells assessed as accumulation at SubG1 phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 5%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
6. | ALA4736498 | Functional | Cell cycle arrest in human M21 cells assessed as accumulation at G0/G1 phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 65.5%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
7. | ALA4736499 | Functional | Cell cycle arrest in human M21 cells assessed as accumulation at S phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 16.1%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
8. | ALA4736500 | Functional | Cell cycle arrest in human M21 cells assessed as accumulation at G2/M phase at 2 to 5 times IC50 measured after 24 hrs by DAPI staining based flow cytometry (Rvb = 13.4%) | Homo sapiens | 11 | ALA4732153 | cell-based format | Scientific Literature | |
9. | ALA4736506 | Binding | Disruption of microtubule polymerization in human M21 cells at 5 times IC50 measured after 24 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 6 | ALA4732153 | cell-based format | Scientific Literature | |
10. | ALA4736507 | Binding | Disruption of microtubule polymerization in human M21 cells assessed as induction of mitotic abnormalities at 5 times IC50 measured after 24 hrs by DAPI staining based immunofluorescence microscopic analysis | Homo sapiens | 6 | ALA4732153 | cell-based format | Scientific Literature | |
11. | ALA4736515 | Binding | Inhibition of EBI binding to colchicine-binding site of beta-tubulin in human M21 cells at 100 to 1000 times IC50 preincubated for 2 hrs followed by EBI addition and measured after 1.5 hrs by Western blot analysis | Homo sapiens | 7 | ALA4732153 | cell-based format | Scientific Literature |