# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4710535 | Binding | Inhibition of human ANO1 channel expressed in HEK293 cells at 10 uM incubated for 10 mins by FLIPR assay relative to control | Homo sapiens | 36 | ALA4706565 | cell-based format | Scientific Literature | |
2. | ALA4710536 | Binding | Inhibition of human ANO1 channel expressed in HEK293 cells incubated for 10 mins by FLIPR assay | Homo sapiens | 10 | ALA4706565 | cell-based format | Scientific Literature | |
3. | ALA4710537 | Binding | Inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells assessed as inhibition of ATP-induced channel current amplitude at membrane potential of +80 mV by patch clamp electrophysiology assay | Mus musculus | 11 | ALA4706565 | cell-based format | Scientific Literature | |
4. | ALA4710538 | ADME | Antiproliferative activity against mouse primary astrocytes assessed as reduction in cell viability at 100 uM measured after 72 hrs by Celltiter-Glo luminescent assay | Mus musculus | 8 | ALA4706565 | cell-based format | Scientific Literature | |
5. | ALA4710540 | Functional | Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability at 100 uM measured after 72 hrs by Celltiter-glo assay | Homo sapiens | 5 | ALA4706565 | cell-based format | Scientific Literature | |
6. | ALA4710541 | Functional | Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability at 100 uM measured after 72 hrs by Celltiter-glo assay | Homo sapiens | 5 | ALA4706565 | cell-based format | Scientific Literature | |
7. | ALA4710549 | Functional | Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay | Homo sapiens | 10 | ALA4706565 | cell-based format | Scientific Literature |