# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4668049 | Binding | Selectivity index, ratio of IC50 for human serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method to IC50 for human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | Homo sapiens | 26 | ALA4665668 | assay format | Scientific Literature | |
2. | ALA4668050 | Binding | Inhibition of human BACE-1 using MOCA-SEV-NL-DAEFR-DNP-RR as substrate preincubated with substrate followed by enzyme addition by FRET assay | Homo sapiens | 31 | ALA4665668 | single protein format | Scientific Literature | |
3. | ALA4668051 | Binding | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | Homo sapiens | 32 | ALA4665668 | cell-free format | Scientific Literature | |
4. | ALA4668052 | Binding | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | Homo sapiens | 32 | ALA4665668 | tissue-based format | Scientific Literature | |
5. | ALA4668056 | ADME | Permeability of the compound in PBS/EtOH buffer (7:3) at 25 ug/ml after 18 hrs by PAMPA-BBB assay | 7 | ALA4665668 | assay format | Scientific Literature | ||
6. | ALA4668057 | Binding | Displacement of propidium iodide from PAS region of human erythrocytes AChE at 10 uM incubated for 6 hrs by fluorescence assay relative to control | Homo sapiens | 7 | ALA4665668 | tissue-based format | Scientific Literature | |
7. | ALA4668058 | Binding | Displacement of propidium iodide from PAS region of human erythrocytes AChE at 50 uM incubated for 6 hrs by fluorescence assay relative to control | Homo sapiens | 7 | ALA4665668 | tissue-based format | Scientific Literature |