| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4703300 | B | Activation of Nrf2 in human HepG2 cells co-transfected with ARE luciferase gene assessed as increase in ARE-driven luciferase activity by luciferase reporter gene assay | Homo sapiens | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 2. | ALA4703302 | F | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as cell viability at 12.8 uM incubated for 12 hrs by calcein AM dye and propidium iodide staining based analysis (Rvb = 50%) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 3. | ALA4703303 | F | Antioxidant activity assessed as DPPH radical scavenging activity | 1 | ALA4699553 | assay format | Scientific Literature | ||
| 4. | ALA4703304 | F | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as live cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 15.03 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 5. | ALA4703305 | F | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as early apoptotic cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 79.84 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 6. | ALA4703306 | F | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as late apoptotic cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 4.62 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 7. | ALA4703307 | F | Neuroprotective activity against glutamate-induced cell death in mouse HT22 cells assessed as necrotic cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 0.51 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 8. | ALA4703308 | F | Neuroprotective activity against glutamate-induced oxidative stress in mouse HT22 cells assessed as reduction in intracellular ROS accumulation at 12.8 uM by DCF-DA staining based fluorescence assay | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 9. | ALA4703309 | F | Neuroprotection against glutamate-induced Ca2+ homeostasis disruption in mouse HT22 cells assessed as reduction in intracellular Ca2+ uptake at 1.4 to 12.8 uM by Fluo3-AM staining based fluorescent microscopic method | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 10. | ALA4703310 | B | Inhibition of glutamate-induced JNK activation in mouse HT22 cells assessed as reduction in phosphorylated JNK protein level by Western blot analysis | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 11. | ALA4703311 | B | Inhibition of glutamate-induced ERK activation in mouse HT22 cells assessed as reduction in phosphorylated ERK protein level by Western blot analysis | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 12. | ALA4703312 | B | Inhibition of glutamate-induced p38 MAPK activation in mouse HT22 cells assessed as reduction in phosphorylated p38 MAPK protein level by Western blot analysis | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 13. | ALA4703313 | F | Neuroprotection against glutamate-induced apoptosis in mouse HT22 cells assessed as reduction in bax protein level at 1.4 to 12.8 uM by Western blot analysis | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 14. | ALA4703314 | F | Neuroprotection against glutamate-induced apoptosis in mouse HT22 cells assessed as increase in bcl2 protein level at 1.4 to 12.8 uM by Western blot analysis | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 15. | ALA4703315 | F | Neuroprotection against glutamate-induced apoptosis in mouse HT22 cells assessed as decrease in translocation of AIF to nucleus at 12.8 uM by Western blot analysis | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 16. | ALA4703316 | F | Neuroprotective activity against 6-OHDA induced neuronal dysfunction in Caenorhabditis elegans N2 assessed as increase in number of body bending at 100 uM incubated for 1 hr and measured for 20 sec | Caenorhabditis elegans | 1 | ALA4699553 | organism-based format | Scientific Literature | |
| 17. | ALA4703317 | A | Induction of apoptosis in mouse HT22 cells assessed as viable cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 87.05 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 18. | ALA4703318 | A | Induction of apoptosis in mouse HT22 cells assessed as early apoptotic cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 3.37 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 19. | ALA4703319 | A | Induction of apoptosis in mouse HT22 cells assessed as late apoptotic cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 7.05 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature | |
| 20. | ALA4703320 | A | Induction of apoptosis in mouse HT22 cells assessed as necrotic cells at 12.8 uM by Annexin-V FITC and propidium iodide staining based flow cytometric analysis (Rvb = 2.53 %) | Mus musculus | 1 | ALA4699553 | cell-based format | Scientific Literature |
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