# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4717656 | Functional | Antiarrhythmic activity in 50 Hz sinusoidal alternating current-induced guinea pig left atrium arrhythmias model assessed as increase in threshold of ac-arrhythmia at 1 x 10^-5 M measured for every 30 mins relative to control | Cavia porcellus | 2 | ALA4715731 | tissue-based format | Scientific Literature | |
2. | ALA4717658 | Functional | Antiarrhythmic activity in 50 Hz sinusoidal alternating current-induced guinea pig left atrium arrhythmias model assessed as increase in threshold of ac-arrhythmia measured for every 30 mins relative to control | Cavia porcellus | 5 | ALA4715731 | tissue-based format | Scientific Literature | |
3. | ALA4717662 | ADME | Negative inotropic activity in guinea pig left atrium assessed as decrease in 1 Hz driven developed tension at 1 x 10^-7 M relative to control | Cavia porcellus | 1 | ALA4715731 | tissue-based format | Scientific Literature | |
4. | ALA4717663 | ADME | Negative inotropic activity in guinea pig left atrium assessed as decrease in 1 Hz driven developed tension | Cavia porcellus | 5 | ALA4715731 | tissue-based format | Scientific Literature | |
5. | ALA4717664 | ADME | Negative inotropic activity in guinea pig spontaneously beating right atrium assessed as decrease in developed tension at 5 x 10^-6 M relative to control | Cavia porcellus | 2 | ALA4715731 | tissue-based format | Scientific Literature | |
6. | ALA4717666 | ADME | Negative inotropic activity in guinea pig spontaneously beating right atrium assessed as decrease in developed tension | Cavia porcellus | 3 | ALA4715731 | tissue-based format | Scientific Literature | |
7. | ALA4717667 | ADME | Negative chronotropic activity in guinea pig spontaneously beating right atrium assessed as decrease in atrial rate at 1 x 10^-5 M relative to control | Cavia porcellus | 3 | ALA4715731 | tissue-based format | Scientific Literature | |
8. | ALA4717671 | ADME | Inhibition of calcium-induced contraction in K+-depolarized guinea pig aortic strips at 1 x 10^-4 M relative to control | Cavia porcellus | 5 | ALA4715731 | tissue-based format | Scientific Literature | |
9. | ALA4717674 | ADME | Inhibition of calcium-induced contraction in K+-depolarized guinea pig longitudinal smooth muscle at 1 x 10^-5 M relative to control | Cavia porcellus | 2 | ALA4715731 | tissue-based format | Scientific Literature | |
10. | ALA4717675 | ADME | Inhibition of calcium-induced contraction in K+-depolarized guinea pig longitudinal smooth muscle | Cavia porcellus | 5 | ALA4715731 | tissue-based format | Scientific Literature | |
11. | ALA4717676 | Toxicity | Toxicity in mouse assessed as motor coordination impairment by measuring number of falls from rotarod at 25 mg/kg, ip measured after 30 mins by rotarod test | Mus musculus | 5 | ALA4715731 | organism-based format | Scientific Literature | |
12. | ALA4717677 | Toxicity | Toxicity in mouse assessed as motor coordination impairment by measuring number of falls from rotarod at 25 mg/kg, ip measured after 45 mins by rotarod test | Mus musculus | 5 | ALA4715731 | organism-based format | Scientific Literature | |
13. | ALA4717678 | Toxicity | Toxicity in mouse assessed as motor coordination impairment by measuring number of falls from rotarod at 25 mg/kg, ip measured after 60 mins by rotarod test | Mus musculus | 4 | ALA4715731 | organism-based format | Scientific Literature | |
14. | ALA4717679 | Toxicity | Toxicity in mouse assessed as motor coordination impairment by measuring number of falls from rotarod at 50 mg/kg, ip measured after 30 mins by rotarod test | Mus musculus | 5 | ALA4715731 | organism-based format | Scientific Literature | |
15. | ALA4717680 | Toxicity | Toxicity in mouse assessed as motor coordination impairment by measuring number of falls from rotarod at 50 mg/kg, ip measured after 45 mins by rotarod test | Mus musculus | 5 | ALA4715731 | organism-based format | Scientific Literature | |
16. | ALA4717681 | Toxicity | Toxicity in mouse assessed as motor coordination impairment by measuring number of falls from rotarod at 50 mg/kg, ip measured after 60 mins by rotarod test | Mus musculus | 4 | ALA4715731 | organism-based format | Scientific Literature | |
17. | ALA4717682 | ADME | Cytotoxicity against human HepG2 cells at EC50 concentration incubated for 2 hrs by MTT assay | Homo sapiens | 4 | ALA4715731 | cell-based format | Scientific Literature | |
18. | ALA4717683 | ADME | Cytotoxicity against human HepG2 cells at 10 times of EC50 concentration incubated for 2 hrs by MTT assay | Homo sapiens | 4 | ALA4715731 | cell-based format | Scientific Literature | |
19. | ALA4717685 | ADME | Binding affinity to P-gp in dog MDCK-MDR1 cells using calcein-AM as substrate after 30 mins by fluorescence analysis | Canis lupus familiaris | 2 | ALA4715731 | cell-based format | Scientific Literature | |
20. | ALA4717686 | Functional | Potency index, ratio of mexiletine EC50 to test compound EC50 for antiarrhythmic activity in guinea pig left atrium model of current induced arrhythmias assessed as increase in threshold of ac-arrhythmia | Cavia porcellus | 2 | ALA4715731 | tissue-based format | Scientific Literature |