| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4729976 | B | Inhibition of CD73 in human CD8+ T-cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and measured after 1 hr by LC-MS/MS analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 2. | ALA4729977 | A | Cmax in rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA4729978 | B | Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins by malachite green reagent based assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 4. | ALA4729979 | B | Inhibition of CD73 in human NCI-H1568 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and measured after 1 hr by LC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA4729983 | B | Inhibition of CD73 in mouse EMT6 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and measured after 1 hr by LC-MS/MS analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4729984 | A | AUC infinity in mouse at 200 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4729985 | A | Cmax in mouse at 200 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA4729986 | A | Terminal half life in mouse at 200 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA4729987 | A | Clearance in rat at 0.2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4729988 | A | Clearance in dog at 0.2 mg/kg, iv | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4729989 | A | Clearance in cynomolgus monkey at 0.2 mg/kg, iv | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4729990 | A | AUC in rat at 0.2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4729991 | A | AUC in dog at 0.2 mg/kg, iv | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4729992 | A | AUC in cynomolgus monkey at 0.2 mg/kg, iv | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4729993 | A | Volume of distribution at steady state in rat at 0.2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4729994 | A | Volume of distribution at steady state in dog at 0.2 mg/kg, iv | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4729995 | A | Volume of distribution at steady state in cynomolgus monkey at 0.2 mg/kg, iv | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4729996 | A | Terminal half life in rat at 0.2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4729997 | A | Terminal half life in dog at 0.2 mg/kg, iv | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4729998 | A | Terminal half life in cynomolgus monkey at 0.2 mg/kg, iv | Macaca fascicularis | 1 | organism-based format | Scientific Literature |
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