# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4670983 | F | Effect on CD69 expression in human PBMC | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
2. | ALA4670985 | B | Binding affinity to human PD1-L1 (18-134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by MST analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
3. | ALA4670986 | B | Binding affinity to mouse PD1-L1 (19-134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by MST analysis | Mus musculus | 4 | assay format | Scientific Literature | ||
4. | ALA4670987 | B | Inhibition of PD-1/PD-L1 immune checkpoint using PD-L1 expressing human aAPCs and PD-1 expressing human PBMC assessed as increase in PD-1 receptor expression on surface of CD8+ T cells incubated for 48 hrs by flow cytometry | Homo sapiens | 1 | assay format | Scientific Literature | ||
5. | ALA4670988 | B | Inhibition of PD-1/PD-L1 immune checkpoint using PD-L1 expressing human aAPCs and PD-1 expressing human PBMC assessed as increase in PD-1 receptor expression on surface of CD4+ T cells incubated for 48 hrs by flow cytometry | Homo sapiens | 1 | assay format | Scientific Literature | ||
6. | ALA4670989 | T | Toxicity in human Jurkat cells at >100 uM incubated for 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4670993 | B | Inhibition of hPD-1/hPD-L1 immune checkpoint using PD-L1 expressing human aAPCs and PD-1 expressing human Jurkat cells assessed as activation of effector Jurkat T cells incubated for 6 hrs by luciferase reporter gene based immune checkpoint blockade cell-based assay | 10 | cell-based format | Scientific Literature | |||
8. | ALA4670994 | B | Inhibition of hPD-1/hPD-L1 immune checkpoint using PD-L1 expressing human aAPCs and PD-1 expressing human Jurkat cells assessed as activation of effector Jurkat T cells at 50 uM incubated for 6 hrs by luciferase reporter gene based immune checkpoint blockade cell-based assay relative to control | 1 | cell-based format | Scientific Literature | |||
9. | ALA4670995 | B | Inhibition of hPD-1/hPD-L1 immune checkpoint using PD-L1 expressing human aAPCs and PD-1 expressing human Jurkat cells assessed as activation of effector Jurkat T cells at 0.01 to 100 uM incubated for 6 hrs by luciferase reporter gene based immune checkpoint blockade cell-based assay | 10 | cell-based format | Scientific Literature | |||
10. | ALA4670996 | B | Binding affinity to human PD-L1 (18 to 134 residues) assessed as induction of protein dimerization by 1H NMR method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
11. | ALA4670997 | B | Binding affinity to Fc-tagged human PD-1 assessed as induction of dissociation of PD-1 N66A mutant/His-and Fc-tagged human PD-L1complex pre-incubated for 30 mins with PDL1 and measured after 1 hr by competitive ELISA | Homo sapiens | 2 | assay format | Scientific Literature | ||
12. | ALA4670999 | B | Binding affinity to human PD1 (34-150 residues) extracellular domain C93S mutant expressed in Escherichia coli BL21 (DE3) incubated for 2 hrs by TR-FRET assay | Homo sapiens | 38 | assay format | Scientific Literature |