# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4674777 | Binding | Agonist activity at PPARalpha/PPARgamma in human AT-MSC cells assessed as upregulation of HMGCR mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
2. | ALA4674780 | Binding | Agonist activity at PPARalpha/PPARgamma in human AT-MSC cells assessed as upregulation of ACAT1 mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
3. | ALA4674781 | Binding | Agonist activity at PPARalpha/PPARgamma in human AT-MSC cells assessed as upregulation of FABP4 mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
4. | ALA4674784 | Binding | Agonist activity at PPARalpha/PPARgamma in human AT-MSC cells assessed as upregulation of adiponectin mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
5. | ALA4674785 | Binding | Binding affinity to human recombinant PPARgamma by Cheng-Prusoff equation based competitive binding TR-FRET assay | Homo sapiens | 3 | ALA4673218 | single protein format | Scientific Literature | |
6. | ALA4674786 | Binding | Binding affinity to human recombinant PPARalpha by Cheng-Prusoff equation based competitive binding TR-FRET assay | Homo sapiens | 3 | ALA4673218 | single protein format | Scientific Literature | |
7. | ALA4674792 | Functional | Induction of adipogenesis in human AT-MSC assessed as adiponectin secretion in IDX medium incubated for 5 days by ELISA | Homo sapiens | 5 | ALA4673218 | tissue-based format | Scientific Literature | |
8. | ALA4674793 | Functional | Induction of adipogenesis in human AT-MSC cells assessed as increase in lipid droplet at 30 uM in IDX medium incubated for 5 days by Oil Red O staining based inverted phase microscopy relative to IDX control | Homo sapiens | 4 | ALA4673218 | cell-based format | Scientific Literature | |
9. | ALA4674794 | Functional | Induction of adipogenesis in human AT-MSC assessed as adiponectin secretion at 30 uM in IDX medium incubated for 5 days by ELISA relative to IDX control | Homo sapiens | 4 | ALA4673218 | tissue-based format | Scientific Literature | |
10. | ALA4674795 | Functional | Induction of adipogenesis in human AT-MSC cells assessed as increase in intracellular lipid accumulation at 30 uM in IDX medium incubated for 5 days by Oil Red O staining based inverted phase microscopy relative to IDX control | Homo sapiens | 4 | ALA4673218 | cell-based format | Scientific Literature | |
11. | ALA4674796 | Functional | Induction of adipogenesis in human AT-MSC assessed as adiponectin secretion at 30 uM in IDX medium incubated for 5 days by ELISA (Rvb = 100 +/- 15 pg/ml) | Homo sapiens | 12 | ALA4673218 | tissue-based format | Scientific Literature | |
12. | ALA4674798 | Functional | Inhibition of UVB-induced MMP1 level in human NHEK cells at 10 uM incubated for 24 hrs by ELISA | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
13. | ALA4674799 | Functional | Inhibition of UVB-induced PGE2 level in human NHEK cells at 10 uM incubated for 24 hrs by ELISA | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
14. | ALA4674802 | Functional | Inhibition of UVB-induced MMP1 mRNA in human NHEK cells at 10 uM incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
15. | ALA4674804 | Functional | Inhibition of UVB-induced PTGS2 mRNA in human NHEK cells at 10 uM incubated for 24 hrs by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
16. | ALA4674808 | Binding | Agonist activity at PPARalpha/PPARgamma in human NHEK cells assessed as upregulation of FASN mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
17. | ALA4674809 | Binding | Agonist activity at PPARalpha/PPARgamma in human NHEK cells assessed as upregulation of ACACB mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
18. | ALA4674810 | Binding | Agonist activity at PPARalpha/PPARgamma in human NHEK cells assessed as upregulation of HMGCR mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 3 | ALA4673218 | cell-based format | Scientific Literature | |
19. | ALA4674811 | Binding | Agonist activity at PPARalpha/PPARgamma in human NHEK cells assessed as upregulation of SCD1 mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 2 | ALA4673218 | cell-based format | Scientific Literature | |
20. | ALA4674812 | Binding | Agonist activity at PPARalpha/PPARgamma in human NHEK cells assessed as upregulation of FADS1 mRNA at 10 uM incubated for 3 days by qRT-PCR analysis | Homo sapiens | 2 | ALA4673218 | cell-based format | Scientific Literature |