# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4666535 | Functional | Protection against oligomycin-induced mitochondrial stress in Caenorhabditis elegans CL4176 assessed as effect oxygen consumption rate at 100 uM after 48 hrs by seahorse XFe96 analyser based assay | Caenorhabditis elegans | 1 | ALA4665634 | organism-based format | Scientific Literature | |
2. | ALA4666536 | Functional | Effect on skn-1 mRNA expression in Caenorhabditis elegans CL4176 at 50 uM by qRT-PCR analysis | Caenorhabditis elegans | 1 | ALA4665634 | assay format | Scientific Literature | |
3. | ALA4666539 | Physicochemical | Solubility of the compound in water | 1 | ALA4665634 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4666540 | Binding | Inhibition of Zn2+ induced amyloid beta (1 to 40) aggregation assessed as reduction in fluorescence intensity at 20 uM preincubated for 5 mins in presence of ZnCl2 followed by compound addition addition and incubated for 24 hrs by Thioflavin T based fluorometric assay | 1 | ALA4665634 | assay format | Scientific Literature | ||
5. | ALA4666541 | Binding | Inhibition of Zn2+ induced amyloid beta (1 to 42) aggregation assessed as reduction in fibril formation incubated for 24 hrs in presence of Zn2+ by Thioflavin T based fluorometric assay | 1 | ALA4665634 | assay format | Scientific Literature | ||
6. | ALA4666542 | Binding | Disaggregation of Zn2+ induced fibrils of amyloid beta (1 to 40) assessed as appearance of small soluble fragments at 0.1 to 100 uM incubated for 24 hrs uranyl acetate staining-based by TEM analysis | 1 | ALA4665634 | assay format | Scientific Literature | ||
7. | ALA4666543 | Binding | Inhibition of self-induced aggregation amyloid beta (1 to 42) (unknown origin) assessed as reduction in fibril formation incubated for 24 hrs by Thioflavin T based fluorometric assay | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
8. | ALA4666544 | Binding | Inhibition of Cu2+ induced amyloid beta (1 to 40) aggregation assessed as reduction in fluorescence intensity at 20 uM preincubated for 5 mins in presence of CuCl2 followed by compound addition addition and incubated for 24 hrs by Thioflavin T based fluorometric assay | 1 | ALA4665634 | assay format | Scientific Literature | ||
9. | ALA4666545 | Binding | Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregation assessed as decrease in negative band ellipticity and shift around 230 nm resulting in inhibition of beta-sheets formation at 80 uM incubated for 24 hrs by circular dichroism spectroscopy | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
10. | ALA4666546 | Binding | Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregation assessed as decrease in negative band ellipticity and shift around 230 nm resulting in modulation of amyloid beta (1 to 42) conformation at 80 uM incubated for 24 hrs by circular dichroism spectroscopy | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
11. | ALA4666547 | Binding | Inhibition of Zn2+ induced amyloid beta (1 to 40) aggregation assessed as appearance of granule like species at 0.1 to 100 uM incubated for 24 hrs uranyl acetate staining-based by TEM analysis | 1 | ALA4665634 | assay format | Scientific Literature | ||
12. | ALA4666548 | Binding | Inhibition of Cu2+ induced amyloid beta (1 to 40) aggregation assessed as appearance of granule like species at 0.1 to 100 uM incubated for 24 hrs uranyl acetate staining-based by TEM analysis | 1 | ALA4665634 | assay format | Scientific Literature | ||
13. | ALA4666549 | Binding | Disaggregation of Cu2+ induced fibrils of amyloid beta (1 to 40) assessed as appearance of small soluble fragments at 0.1 to 100 uM incubated for 24 hrs uranyl acetate staining-based by TEM analysis | 1 | ALA4665634 | assay format | Scientific Literature | ||
14. | ALA4666550 | ADME | Cytotoxicity against rat PC-12 cells assessed as reduction in cell viability at 100 uM measured after 48 hrs by MTT assay relative to control | Rattus norvegicus | 1 | ALA4665634 | cell-based format | Scientific Literature | |
15. | ALA4666551 | Binding | Inhibition of amyloid beta (1 to 42)-induced paralysis in transgenic Caenorhabditis elegans CL4176 expressing human amyloid beta (1 to 42) assessed as paralyzed worms at 50 uM treated for 49 hrs at 25 degreeC by microscopic analysis (Rvb = 87 %) | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
16. | ALA4666552 | Binding | Inhibition of amyloid beta (1 to 42)-induced paralysis in transgenic Caenorhabditis elegans CL4176 expressing human amyloid beta (1 to 42) assessed as paralyzed worms at 100 uM treated for 49 hrs at 25 degreeC by microscopic analysis (Rvb = 87 %) | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
17. | ALA4666553 | Binding | Inhibition of amyloid beta (1 to 42)-induced paralysis in transgenic Caenorhabditis elegans CL4176 expressing human amyloid beta (1 to 42) assessed as paralyzed worms at 200 uM treated for 49 hrs at 25 degreeC by microscopic analysis (Rvb = 87 %) | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
18. | ALA4666554 | Binding | Inhibition of amyloid beta (1 to 42)-induced paralysis in transgenic Caenorhabditis elegans GMC101 expressing human amyloid beta (1 to 42) assessed as paralyzed worms at 50 uM measured after 92 hrs by microscopic analysis relative to control | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
19. | ALA4666555 | Binding | Inhibition of amyloid beta (1 to 42)-induced paralysis in transgenic Caenorhabditis elegans GMC101 expressing human amyloid beta (1 to 42) assessed as paralyzed worms at 100 uM measured after 92 hrs by microscopic analysis relative to control | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature | |
20. | ALA4666556 | Binding | Inhibition of amyloid beta (1 to 42)-induced paralysis in transgenic Caenorhabditis elegans GMC101 expressing human amyloid beta (1 to 42) assessed as paralyzed worms at 200 uM measured after 92 hrs by microscopic analysis relative to control | Homo sapiens | 1 | ALA4665634 | single protein format | Scientific Literature |