| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4732719 | B | Irreversible inhibition of Clostridium botulinum BoNT/A light chain (1 to 425 residues) assessed as ratio of Kinact/Ki using SNAPtide flp6 as substrate inhibited for 1 hr by FRET assay | Clostridium botulinum | 6 | ALA4732040 | single protein format | Scientific Literature | |
| 2. | ALA4732720 | P | GSH reactivity assessed as pseudo first order rate constant at 1 mM in presence of glutathione | 7 | ALA4732040 | small-molecule physicochemical format | Scientific Literature | ||
| 3. | ALA4732721 | P | GSH reactivity assessed as half life at 1 mM in presence of glutathione | 7 | ALA4732040 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA4732722 | B | Time dependent inhibition of Clostridium botulinum BoNT/A light chain (1 to 425 residues) at 50 uM using SNAPtide flp6 as substrate incubated for 3 hrs by FRET assay relative to control | Clostridium botulinum | 2 | ALA4732040 | single protein format | Scientific Literature | |
| 5. | ALA4732723 | B | Time dependent inhibition of Clostridium botulinum BoNT/A light chain (1 to 425 residues) using SNAPtide flp6 as substrate by FRET assay | Clostridium botulinum | 36 | ALA4732040 | single protein format | Scientific Literature | |
| 6. | ALA4732725 | B | Irreversible inhibition of Clostridium botulinum BoNT/A light chain (1 to 425 residues) at 50 uM using SNAPtide flp6 as substrate preincubated for 1 hr followed by substrate addition and measured after 5 to 10 mins by FRET assay | Clostridium botulinum | 2 | ALA4732040 | single protein format | Scientific Literature | |
| 7. | ALA4732728 | B | Inhibition of Clostridium botulinum BoNT/A light chain (1 to 425 residues) assessed as compound-enzyme adduct formation at 100 uM incubated for 1 hr by HRMS analysis | Clostridium botulinum | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 8. | ALA4732729 | B | Time dependent inhibition of Clostridium botulinum BoNT/A light chain C165A mutant (1 to 425 residues) at 50 uM using SNAPtide flp6 as substrate preincubated for 1 hr followed by substrate addition and measured after 5 to 10 mins by FRET assay | Clostridium botulinum | 3 | ALA4732040 | assay format | Scientific Literature | |
| 9. | ALA4732730 | P | Solubility of compound at 0.25 to 50 mM incubated for 2 hrs by UV/Vis spectroscopic analysis | 3 | ALA4732040 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA4732731 | B | Inhibition of Clostridium botulinum BoNT/A intoxicated in hiPSC-derived neurons assessed as reduction in SNAP-25 cleavage at 100 uM using SNAP-25 as substrate treated 30 mins post toxin addition and measured 7.5 hrs post toxin addition by Western blot analysis relative to control | Clostridium botulinum | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 11. | ALA4732734 | A | Cytotoxicity against human iPSC assessed as cell rounding at 100 uM incubated for 7.5 hrs | Homo sapiens | 2 | ALA4732040 | tissue-based format | Scientific Literature | |
| 12. | ALA4732735 | A | Inhibition of MMP-1 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 13. | ALA4732736 | A | Inhibition of MMP-2 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 14. | ALA4732737 | A | Inhibition of MMP-3 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 15. | ALA4732738 | A | Inhibition of MMP-7 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 16. | ALA4732739 | A | Inhibition of MMP-8 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 17. | ALA4732740 | A | Inhibition of MMP-12 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 18. | ALA4732741 | A | Inhibition of MMP-13 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 19. | ALA4732742 | A | Inhibition of MMP-14 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature | |
| 20. | ALA4732743 | A | Inhibition of MMP-19 (unknown origin) at 25 uM using TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as substrate bu fluorometric analysis | Homo sapiens | 3 | ALA4732040 | single protein format | Scientific Literature |
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