| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4711508 | B | Modulation of P-gp1 in dog MDCK-MDR1 cells assessed as inhibition of calcein-AM transport using calcein-AM as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence analysis | Canis lupus familiaris | 18 | cell-based format | Scientific Literature | ||
| 2. | ALA4711509 | B | Modulation of MRP1 in dog MDCK-MRP1 cells assessed as inhibition of calcein-AM transport using calcein-AM as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence analysis | Canis lupus familiaris | 18 | cell-based format | Scientific Literature | ||
| 3. | ALA4711510 | B | Modulation of BCRP in dog MDCK-BCRP cells assessed as inhibition of rhodamine-123 transport using rhodamine 123 as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence analysis | Canis lupus familiaris | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA4711511 | A | Modulation of P-gp in human Caco-2 cells assessed as efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 5. | ALA4711512 | B | Modulation of P-gp1 in dog MDCK-MDR1 cells assessed as induction of ATP cell depletion preincubated for 2 hrs followed by substrate addition and measured after 10 mins in dark by ATPlite luminescence assay | Canis lupus familiaris | 18 | cell-based format | Scientific Literature | ||
| 6. | ALA4711513 | A | Cytotoxicity against dog MDCK-MDR1 cells at 100 to 1000 nM incubated for 48 to 72 hrs by MTT assay | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4711514 | B | Modulation of P-gp1 in dog MDCK-MDR1 cells assessed as potentiation of doxorubicin-induced cytotoxicity at 500 to 1000 nM preincubated for 1 day followed by removal of medium and later subsequently incubated with compound and doxorubicin and measured after 48 hrs by MTT assay | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4711515 | A | Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability at >=10 uM incubated for 48 to 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4711516 | A | Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability at 100 nM incubated for 48 to 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4711517 | A | Effect on electrophysiological property of human Caco-2 cells barrier model assessed as apparent permeability of luciferin yellow across apical to basolateral side at 100 nM incubated for 2 hrs after cell culturing in Transwell systems for 21 days by spectrofluorimetric method (Rvb = 2.29 +/- 0.63 nmol/s) | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4711518 | A | Effect on electrophysiological property of human Caco-2 cells barrier model assessed as apparent permeability of sulforhodamine B across apical to basolateral side at 100 nM incubated for 2 hrs after cell culturing in Transwell systems for 21 days by spectrofluorimetric method (Rvb = 2.12 +/- 0.23 nmol/s) | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA4711519 | A | Effect on electrophysiological property of human Caco-2 cells barrier model assessed as apparent permeability of FITC-insulin across apical to basolateral side in human Caco2 cells at 100 nM incubated for 2 hrs after cell culturing in Transwell systems for 21 days by spectrofluorimetric method (Rvb = 0.15 +/- 0.04 nmol/s) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4711520 | B | Inhibition of P-gp in human Caco-2 cells assessed as reduction in ATPase activity at 100 nM after 2 hrs by spectrophotometric method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4711521 | B | Inhibition of MRP1 in human Caco-2 cells assessed as reduction in ATPase activity at 100 nM after 2 hrs by spectrophotometric method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4711522 | B | Induction of P-gp mediated transport of [3H]-digoxin across apical to basolateral side in human Caco2 cells at 100 nM incubated for 2 hrs by liquid scintillation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4711523 | B | Induction of P-gp mediated transport of [3H]-quinidine across apical to basolateral side in human Caco2 cells at 100 nM incubated for 2 hrs by liquid scintillation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4711524 | B | Induction of P-gp mediated transport of [3H]-prazosin across apical to basolateral side in human Caco2 cells at 100 nM incubated for 2 hrs by liquid scintillation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4711525 | B | Induction of P-gp mediated transport of [3H]-carbamazepine across apical to basolateral side in human Caco2 cells at 100 nM incubated for 2 hrs by liquid scintillation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4711526 | B | Induction of P-gp mediated transport of [3H]-imipramine across apical to basolateral side in human Caco2 cells at 100 nM incubated for 2 hrs by liquid scintillation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4711527 | B | Induction of P-gp mediated transport of [3H]-lansoprazole across apical to basolateral side in human Caco2 cells at 100 nM incubated for 2 hrs by liquid scintillation method | Homo sapiens | 1 | cell-based format | Scientific Literature |
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