# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4774603 | A | Cytotoxicity against human HepaRG cells assessed as reduction in cell viability at 10 uM measured after 24 hrs by Celltiter-blue cell viability assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
2. | ALA4774604 | A | Cytotoxicity against human HepaRG cells assessed as reduction in cell viability at 20 uM measured after 24 hrs by Celltiter-blue cell viability assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
3. | ALA4774605 | A | Cytotoxicity against human HepaRG cells overexpressing EGFP-CYP3A4 assessed as reduction in cell viability at 10 uM measured after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA4774606 | F | Cytotoxicity against human HepG2 cells overexpressing EGFP-CYP3A4 assessed as reduction in cell viability at 15 uM measured after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
5. | ALA4774607 | B | Inhibition of P-gp in vincristine-resistant human CEM cells at 0.1 to 1 uM using calcein-AM as substrate preincubated for 30 mins followed by compound washout and subsequent substrate addition measured after 60 mins by flow cytometric analysis | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
6. | ALA4774608 | F | Effect on P-gp expression in vincristine-resistant human CEM cells at 1 uM measured after 1.5 hrs by immunostaining based flow cytometry | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
7. | ALA4774609 | B | Inhibition of P-gp in vincristine-resistant human CEM cells assessed as potentiation of vincristine-induced apoptosis 1 uM measured after 48 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
8. | ALA4774610 | F | Antiproliferative activity against vincristine-resistant human CEM cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-blue cell viability assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
9. | ALA4774611 | B | Effect on AKT phosphorylation at Ser473 residue in vincristine-resistant human CEM cells at 5 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
10. | ALA4774612 | F | Effect on Bcl-XL expression in vincristine-resistant human CEM cells at 5 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
11. | ALA4774613 | F | Effect on MCL1 expression in vincristine-resistant human CEM cells at 5 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
12. | ALA4774614 | F | Induction of apoptosis in vincristine-resistant human CEM cells assessed as increase in PARP cleavage at 5 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4774615 | F | Induction of mitochondrial membrane disruption in vincristine-resistant human CEM cells at 5 uM measured after 24 hrs by JC-1 dye based flow cytometric analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
14. | ALA4774617 | F | Induction of apoptosis in human HepG2 cells assessed as increase in PARP cleavage at 5 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
15. | ALA4774620 | F | Induction of mitochondrial membrane disruption in human HepG2 cells at 5 uM measured after 24 hrs by JC-1 dye based flow cytometric analysis | Homo sapiens | 6 | cell-based format | Scientific Literature |