# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4772124 | Binding | Inhibition of RIPK1 in human FADD-deficient Jurkat I 2.1 cells assessed as reduction in TNFalpha-induced necroptosis measured after 24 hrs by MTS assay | Homo sapiens | 1 | ALA4765378 | tissue-based format | Scientific Literature | |
2. | ALA4772125 | Binding | Inhibition of RIPK1 in human FADD-deficient Jurkat I 2.1 cells assessed as protection against TNFalpha-induced necroptosis by measuring remaining viable cells at 10 uM measured after 24 hrs by MTS assay relative to TNFalpha | Homo sapiens | 56 | ALA4765378 | tissue-based format | Scientific Literature | |
3. | ALA4772126 | Binding | Inhibition of RIPK1 in human FADD-deficient Jurkat I 2.1 cells assessed as protection against TNFalpha-induced necroptosis measured after 24 hrs by MTS assay | Homo sapiens | 55 | ALA4765378 | tissue-based format | Scientific Literature | |
4. | ALA4772127 | ADME | Cytotoxicity against human FADD-deficient Jurkat I 2.1 cells assessed as reduction in cell viability at 10 uM measured after 24 hrs by MTS assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature | |
5. | ALA4772129 | ADME | Cytotoxicity against human FADD-deficient Jurkat I 2.1 cells assessed as reduction in cell viability at >25 uM measured after 24 hrs by MTS assay | Homo sapiens | 1 | ALA4765378 | cell-based format | Scientific Literature | |
6. | ALA4772130 | ADME | Cytotoxicity against human TERT-RPE1 cells assessed as increase in LDH release at 0.01 to 50 uM measured after 24 hrs by CyQUANT reagent based assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature | |
7. | ALA4772131 | Binding | Inhibition of recombinant human RIPK1 kinase domain (8 to 322 residues) using myelin basic protein as substrate measured after 120 mins by [gamma-32P]ATP based scintillation counting method | Homo sapiens | 2 | ALA4765378 | single protein format | Scientific Literature | |
8. | ALA4772136 | Binding | Inhibition of human CDK2/cyclin A using histone H1 as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | protein complex format | Scientific Literature | |
9. | ALA4772137 | Binding | Inhibition of human recombinant CDK5/p25 expressed in bacterial expression using histone H1 as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | assay format | Scientific Literature | |
10. | ALA4772138 | Binding | Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature | |
11. | ALA4772139 | Binding | Inhibition of mouse recombinant CLK1 expressed in bacterial expression system using GRSRSRSRSRSR as substrate by ADP-glo assay | Mus musculus | 2 | ALA4765378 | assay format | Scientific Literature | |
12. | ALA4772140 | Binding | Inhibition of recombinant rat DYRK1A kinase domain (1 to 499 residues) expressed in bacterial expression system using KKISGRLSPIMTEQ as substrate by ADP-glo assay | Rattus norvegicus | 2 | ALA4765378 | assay format | Scientific Literature | |
13. | ALA4772141 | Binding | Inhibition of recombinant human HASPIN kinase domain (470 to 798 residues) expressed in bacterial expression system using histone H3(1-21) peptide as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | assay format | Scientific Literature | |
14. | ALA4772142 | Binding | Inhibition of recombinant human PIM1 expressed in bacterial expression system using histone H1 as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | assay format | Scientific Literature | |
15. | ALA4772143 | Binding | Inhibition of recombinant human CK1epsilon expressed in baculovirus infected Sf9 insect cells using RRKHAAIGSpAYSITA as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature | |
16. | ALA4772144 | Binding | Inhibition of recombinant human JAK3 C-terminal domain (781 to 1124 residues) expressed in baculovirus infected Sf9 insect cells using GGEEEEYFELVKKKK as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature | |
17. | ALA4772145 | Binding | Inhibition of recombinant human ABL1 (118 to 535 residues) expressed in baculovirus infected Sf9 insect cells using EAIYAAPFAKKK as substrate by ADP-glo assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature | |
18. | ALA4772146 | Binding | Inhibition of recombinant human RIPK3 expressed in baculovirus infected Sf9 insect cells using myelin basic protein as substrate by ADP-Glo assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature | |
19. | ALA4772147 | Binding | Inhibition of recombinant human AURKB expressed in baculovirus infected Sf9 insect cells using myelin basic protein as substrate by ADP-Glo assay | Homo sapiens | 2 | ALA4765378 | cell-based format | Scientific Literature |