| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4676662 | Binding | Inhibition of N-terminal GST-tagged human full length PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) and biotinylated NAD+ as substrate in presence of activated DNA incubated for 60 mins by chemiluminescence assay | Homo sapiens | 17 | ALA4673259 | cell-based format | Scientific Literature | |
| 2. | ALA4676663 | ADME | Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) and biotinylated NAD+ as substrate in presence of activated DNA incubated for 60 mins by chemiluminescence assay | Homo sapiens | 17 | ALA4673259 | cell-based format | Scientific Literature | |
| 3. | ALA4676664 | Binding | Inhibition of PARP1 in human MDA-MB-436 cells assessed as inhibition of PARylation at 10 nM incubated for 1 hr by chemiluminescence assay | Homo sapiens | 14 | ALA4673259 | cell-based format | Scientific Literature | |
| 4. | ALA4676665 | Functional | Cytotoxicity against human MDA-MB-436 cells assessed as inhibition of cell viability incubated for 4 days by CellTiterGlo luminescence assay | Homo sapiens | 12 | ALA4673259 | cell-based format | Scientific Literature | |
| 5. | ALA4676666 | Functional | Cytotoxicity against human MDA-MB-436 cells assessed as inhibition of cell viability incubated for 14 days with three intermittent intervals by CellTiterGlo luminescence assay | Homo sapiens | 12 | ALA4673259 | cell-based format | Scientific Literature | |
| 6. | ALA4676667 | ADME | Tmax in BALB/c mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 7. | ALA4676668 | ADME | Tmax in BALB/c mouse at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 8. | ALA4676669 | ADME | Cmax in BALB/c mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 9. | ALA4676670 | ADME | Cmax in BALB/c mouse at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 10. | ALA4676671 | ADME | AUClast in BALB/c mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 11. | ALA4676672 | ADME | AUClast in BALB/c mouse at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 12. | ALA4676673 | ADME | Half life in BALB/c mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 13. | ALA4676674 | ADME | Clearance in BALB/c mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 14. | ALA4676675 | ADME | Volume of distribution at steady state in BALB/c mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 15. | ALA4676676 | ADME | Oral bioavailability in BALB/c mouse at 10 mg/kg measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4673259 | organism-based format | Scientific Literature | |
| 16. | ALA4676677 | ADME | Metabolic stability of the compound in mouse liver microsomes assessed as clearance rate at 1 uM preincubated for 5 mins prior to NADPH addition measured per mg protein by LC-MS/MS analysis | Mus musculus | 1 | ALA4673259 | microsome format | Scientific Literature | |
| 17. | ALA4676678 | ADME | Metabolic stability of the compound in rat liver microsomes assessed as clearance rate at 1 uM preincubated for 5 mins prior to NADPH addition measured per mg protein by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4673259 | microsome format | Scientific Literature | |
| 18. | ALA4676679 | ADME | Metabolic stability of the compound in dog liver microsomes assessed as clearance rate at 1 uM preincubated for 5 mins prior to NADPH addition measured per mg protein by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4673259 | microsome format | Scientific Literature | |
| 19. | ALA4676680 | ADME | Metabolic stability of the compound in monkey liver microsomes assessed as clearance rate at 1 uM preincubated for 5 mins prior to NADPH addition measured per mg protein by LC-MS/MS analysis | Macaca mulatta | 1 | ALA4673259 | microsome format | Scientific Literature | |
| 20. | ALA4676681 | ADME | Metabolic stability of the compound in human liver microsomes assessed as clearance rate at 1 uM preincubated for 5 mins prior to NADPH addition measured per mg protein by LC-MS/MS analysis | Homo sapiens | 1 | ALA4673259 | microsome format | Scientific Literature |
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