#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4681440	Binding	Inhibition of GST-tagged MDM2 (amino acids 17 to 111 residues)/p53 (unknown origin) interaction incubated for 15 mins by	Homo sapiens	32	ALA4680091	protein format	Scientific Literature
2.	ALA4681441	Functional	Antitumor activity against human SJSA-1 cells xenografted in BomTac:NMRI-Foxn1^nu mouse assessed as induction of tumor regression at 25 mg/kg, po dosed daily for 13 days	Homo sapiens	1	ALA4680091	organism-based format	Scientific Literature
3.	ALA4681442	Functional	Antitumor activity against human SJSA-1 cells xenografted in BomTac:NMRI-Foxn1^nu mouse assessed as induction of tumor regression at 100 mg/kg, po administered as single dose and measured up to 13 days	Homo sapiens	1	ALA4680091	organism-based format	Scientific Literature
4.	ALA4681443	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of CDKN1a mRNA expression at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by q-RT-PCR analysis	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
5.	ALA4681444	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of MDM2 mRNA expression at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by q-RT-PCR analysis	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
6.	ALA4681445	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of BBC3 mRNA expression at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by q-RT-PCR analysis	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
7.	ALA4681446	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of TP53 protein accumulation at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by mesoscale assay	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
8.	ALA4681447	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of MDM2 protein accumulation at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by mesoscale assay	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
9.	ALA4681448	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of cleaved caspse-3 protein accumulation at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by mesoscale assay	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
10.	ALA4681449	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of CDKN1a protein accumulation at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by immunohistochemical analysis	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
11.	ALA4681450	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of TP53 protein accumulation at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by immunohistochemical analysis	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
12.	ALA4681451	Functional	In-vivo inhibition of MDM2 in BomTac:NMRI-Foxn1^nu mouse xenografted with human SJSA-1 cells assessed as induction of cleaved CASPASE3 protein accumulation at 100 mg/kg, po administered as single dose and measured after 6 to 24 hrs by immunohistochemical analysis	Mus musculus	1	ALA4680091	organism-based format	Scientific Literature
13.	ALA4681452	Functional	Antiproliferative activity against human SJSA-1 cells expression wild type p53 incubated for 3 days by Alamar Blue dye based assay	Homo sapiens	7	ALA4680091	cell-based format	Scientific Literature
14.	ALA4681453	Functional	Antiproliferative activity against human SK-OV-3 cells expression p53 mutant incubated for 3 days by Alamar Blue dye based assay	Homo sapiens	7	ALA4680091	cell-based format	Scientific Literature
15.	ALA4681454	ADME	AUC (0 to 24 hrs) in NMRI mouse at 50 mg/kg, po	Mus musculus	3	ALA4680091	organism-based format	Scientific Literature
16.	ALA4681455	ADME	Cmax in NMRI mouse at 50 mg/kg, po	Mus musculus	3	ALA4680091	organism-based format	Scientific Literature
17.	ALA4681456	ADME	Clearance in NMRI mouse at 5 mg/kg, iv	Mus musculus	3	ALA4680091	organism-based format	Scientific Literature
18.	ALA4681457	ADME	Volume of distribution at steady state in NMRI mouse at 5 mg/kg, iv	Mus musculus	3	ALA4680091	organism-based format	Scientific Literature