| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4712494 | B | Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract preincubated for 30 mins followed by hSIE probe addition by EMSA analysis | Mus musculus | 37 | subcellular format | Scientific Literature | ||
| 2. | ALA4712495 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
| 3. | ALA4712496 | F | Antiproliferative activity against human MDA-MB-468 cells harbouring STAT3 assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 4. | ALA4712497 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 5. | ALA4712498 | A | Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 6. | ALA4712504 | B | Binding affinity to STAT3 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 7. | ALA4712505 | B | Binding affinity to STAT3 (unknown origin) assessed as change in gibbs free energy by isothermal titration calorimetry | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA4712506 | B | Binding affinity to STAT3 (unknown origin) assessed as change in enthalpy by isothermal titration calorimetry | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 9. | ALA4712507 | B | Binding affinity to STAT3 (unknown origin) assessed as change in entropy by isothermal titration calorimetry | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA4712513 | B | Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA hSIE probe binding to STAT3 in human MDA-MB-468 cell nuclear extract at 5 uM by EMSA analysis | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 11. | ALA4712514 | B | Inhibition of STAT3 phosphorylation at Y705 residues in human MDA-MB-231 whole cell lysate by immunoblotting analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 12. | ALA4712518 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as effect on EGFR expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4712519 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as effect on JAK2 expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4712520 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as effect on Src expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4712521 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as effect on Akt expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4712522 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as effect on Erk1/2 expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4712523 | F | Anticlonogenic activity against human MDA-MB-231 cells assessed as inhibition of colony formation at 0.5 uM incubated for 4 hrs by crystal violet staining based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4712526 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as inhibition of c-myc expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4712527 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as inhibition of VEGF expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4712528 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as inhibition of Bcl-2 expression at 1 to 3 uM incubated for 3 to 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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