# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4775410 | B | Competitive antagonist activity at human RXRA/RXRA expressed in African green monkey COS7 cells assessed as reduction in bexarotene-induced receptor activation by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA4775411 | B | Competitive antagonist activity at human PPAR-gamma/RXRA expressed in African green monkey COS7 cells assessed as reduction in bexarotene-induced receptor activation by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA4775412 | B | Competitive antagonist activity at human LXR-alpha/RXRA expressed in African green monkey COS7 cells assessed as reduction in bexarotene-induced receptor activation by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4775413 | B | Competitive antagonist activity at human RXRB/RXRB expressed in African green monkey COS7 cells assessed as reduction in bexarotene-induced receptor activation at 1 uM by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4775414 | B | Competitive antagonist activity at human RXRG/RXRG expressed in African green monkey COS7 cells assessed as reduction in bexarotene-induced receptor activation at 1 uM by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4775415 | B | Competitive antagonist activity at human PPAR-gamma/RXRA expressed in African green monkey COS7 cells assessed as reduction in PPAR pan-agonist TIPP-703-induced receptor activation at 10 uM by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4775416 | B | Competitive antagonist activity at human LXR-alpha/RXRA expressed in African green monkey COS7 cells assessed as reduction in LXR agonist T0901317 -induced receptor activation at 10 uM by RXRE-dependent luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4775417 | B | Binding affinity to human RXR-alpha LBD incubated for 2 hrs by tryptophan fluorescence quenching assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4775418 | B | Displacement of [3H]-9-cis retinoic acid from recombinant human RXR-alpha LBD by liquid scintillation counting based competitive ligand binding assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4775419 | B | Binding affinity to human RXR-alpha by ITC analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4775420 | B | Binding affinity to human RXR-alpha assessed as induction of conformational changes by measuring theta222/theta208 ratio at 15 uM incubated for 2 hrs by CD spectroscopy | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
12. | ALA4775422 | B | Antagonist activity at RXR-alpha in mouse RAW264.7 cells assessed as supression of bexarotene-induced inhibition of LPS-induced NF-kappaB transcription by measuring NF-kappaB level at 0.1 to 10 uM incubated for 24 hrs by SEAP dependent NF-kappaB reporter assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
13. | ALA4775426 | B | Antagonist activity at RXR-alpha in mouse RAW264.7 cells assessed as supression of bexarotene-induced inhibition of LPS-induced suppressed Nos2 gene expression at 10 uM incubated for 6 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
14. | ALA4775427 | B | Antagonist activity at RXR-alpha in mouse RAW264.7 cells assessed as supression of bexarotene-induced inhibition of LPS-induced suppressed NO production at 1 uM incubated for 48 hrs by Griess assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
15. | ALA4775428 | P | Solubility in pH 7.4 PBS at at 1 mM incubated for 6 hrs by HPLC analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA4775429 | T | Toxicity in C57BL6/J mouse assessed as effect on body weight at 10 mg/kg/day, po for 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4775430 | T | Toxicity in C57BL6/J mouse assessed as effect on liver weight/body weight ratio at 10 mg/kg/day, po for 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4775431 | T | Toxicity in C57BL6/J mouse assessed as effect on plasma AST level at 10 mg/kg/day, po for 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA4775432 | T | Toxicity in C57BL6/J mouse assessed as effect on plasma ALT level at 10 mg/kg/day, po for 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
20. | ALA5030469 | B | Antagonist activity at human RXR-alpha expressed in African green monkey COS-1 cells assessed as reduction in NEt-TMN-induced receptor transactivation at 1 uM by luciferase reporter gene assay | Homo sapiens | 3 | cell-based format | Scientific Literature |