# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4734806 | ADME | Substrate activity at FAAH in FAAH+/+ mouse brain assessed as N-arachidonoyl conjugate level per g protein at 0.1 mM measured after 20 mins by LC-MS/MS analysis | Mus musculus | 6 | ALA4732106 | tissue-based format | Scientific Literature | |
2. | ALA4734807 | ADME | Prodrug conversion in FAAH-/- mouse brain assessed as N-arachidonoyl conjugate level per g protein at 0.1 mM measured after 20 mins by LC-MS/MS analysis | Mus musculus | 6 | ALA4732106 | tissue-based format | Scientific Literature | |
3. | ALA4734810 | ADME | Prodrug conversion in FAAH+/+ mouse brain assessed as N-arachidonoyl conjugate level per g protein at 100 mg/kg, ip measured after 20 mins by LC-MS/MS analysis | Mus musculus | 5 | ALA4732106 | organism-based format | Scientific Literature | |
4. | ALA4734812 | ADME | Prodrug conversion in FAAH-/- mouse brain assessed as N-arachidonoyl conjugate level per g protein at 100 mg/kg, ip measured after 20 mins by LC-MS/MS analysis | Mus musculus | 5 | ALA4732106 | organism-based format | Scientific Literature | |
5. | ALA4734814 | Functional | Antinociceptive activity in ip dosed C57BL/6 mouse assessed as reduction in licking time during first phase treated for 10 mins and measured for 5 mins by formalin test | Mus musculus | 2 | ALA4732106 | organism-based format | Scientific Literature | |
6. | ALA4734815 | Functional | Antinociceptive activity in ip dosed C57BL/6 mouse assessed as reduction in licking time during second phase treated for 10 mins and measured for 15 to 40 mins by formalin test | Mus musculus | 2 | ALA4732106 | organism-based format | Scientific Literature | |
7. | ALA4734816 | ADME | Effect on locomotor activity in C57BL/6 mouse assessed as change in latency to fall at 50 to 75 mg/kg, ip treated for 10 mins measured up to 60 mins by rotarod test | Mus musculus | 1 | ALA4732106 | organism-based format | Scientific Literature | |
8. | ALA4734818 | Functional | Antinociceptive activity in C57BL/6 mouse assessed as reduction in licking time during second phase at 50 mg/kg, ip treated for 10 mins and measured for 15 to 40 mins in presence of FAAH inhibitor URB937 by formalin test | Mus musculus | 1 | ALA4732106 | organism-based format | Scientific Literature | |
9. | ALA4734819 | Functional | Antinociceptive activity in C57BL/6 mouse assessed as reduction in licking time during second phase at 50 mg/kg, ip treated for 10 mins and measured for 15 to 40 mins in presence of TRPV1 antagonist capsazepine by formalin test | Mus musculus | 1 | ALA4732106 | organism-based format | Scientific Literature | |
10. | ALA4734824 | Functional | Antinociceptive activity in C57BL/6 mouse assessed as reduction in licking time during first phase at 50 mg/kg, ip treated for 10 mins and measured for 5 mins in presence of FAAH inhibitor URB937 by formalin test | Mus musculus | 1 | ALA4732106 | organism-based format | Scientific Literature | |
11. | ALA4734825 | Functional | Antinociceptive activity in C57BL/6 mouse assessed as reduction in licking time during first phase at 50 mg/kg, ip treated for 10 mins and measured for 5 mins in presence of TRPV1 antagonist capsazepine by formalin test | Mus musculus | 1 | ALA4732106 | organism-based format | Scientific Literature | |
12. | ALA4734849 | Toxicity | Hepatotoxicity in C57BL/6 mouse assessed as change in ALT level at 300 mg/kg, ip measured after 12 hrs | Mus musculus | 5 | ALA4732106 | organism-based format | Scientific Literature | |
13. | ALA4734851 | Toxicity | Hepatotoxicity in C57BL/6 mouse assessed as centrilobular necrosis at 300 mg/kg, ip measured after 12 hrs by H and E staining based microscopic analysis | Mus musculus | 5 | ALA4732106 | organism-based format | Scientific Literature |