# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4704539 | Binding | Inhibition of recombinant human full length PYK2 at 100 nM in presence of [gamma32P]-ATP by radiometric analysis relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
2. | ALA4704547 | Binding | Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Glu, Tyr) as substrate measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 12 | ALA4699600 | cell-based format | Scientific Literature | |
3. | ALA4704548 | Binding | Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Glu, Tyr) as substrate preincubated for 2 to 60 mins followed by substrate addition and measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 4 | ALA4699600 | cell-based format | Scientific Literature | |
4. | ALA4704549 | Binding | Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells assessed as inactivation rate constant using Poly (4:1 Glu, Tyr) as substrate preincubated for 2 to 60 mins followed by substrate addition and measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 4 | ALA4699600 | cell-based format | Scientific Literature | |
5. | ALA4704550 | Binding | Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells assessed as ratio of Kinact to Ki using Poly (4:1 Glu, Tyr) as substrate preincubated for 2 to 60 mins followed by substrate addition and measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 4 | ALA4699600 | cell-based format | Scientific Literature | |
6. | ALA4704554 | Binding | Inhibition of human recombinant Src at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
7. | ALA4704555 | Binding | Inhibition of human recombinant FGFR1 (456 to 765 residues) at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
8. | ALA4704556 | Binding | Inhibition of human recombinant c-kit at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
9. | ALA4704557 | Binding | Inhibition of human recombinant EGFR at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
10. | ALA4704558 | Binding | Inhibition of human recombinant IGF1R at 100 nM by [gamma-33ATP] radiometric assay relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
11. | ALA4704559 | Binding | Inhibition of human recombinant PDGFRA at 100 nM by [gamma-33ATP] radiometric assay relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
12. | ALA4704560 | Binding | Inhibition of human recombinant IR at 100 nM by [gamma-33ATP] radiometric analysis relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
13. | ALA4704561 | Binding | Inhibition of human Akt at 100 nM in presence of [33P]-ATP by radiometric analysis relative to control | Homo sapiens | 4 | ALA4699600 | protein format | Scientific Literature | |
14. | ALA4704562 | Binding | Inhibition of human recombinant Erk at 100 nM measured in presence of [33P]-ATP by radiometric analysis relative to control | Homo sapiens | 4 | ALA4699600 | assay format | Scientific Literature | |
15. | ALA4704563 | Binding | Inhibition of human recombinant FAK at 100 nM by [gamma32P]-ATP radiometric analysis relative to control | Homo sapiens | 4 | ALA4699600 | single protein format | Scientific Literature | |
16. | ALA4704564 | Binding | Inhibition of FAK autophosphorylation at Tyr397 residue in human U87MG cells after 48 hrs by ELISA | Homo sapiens | 5 | ALA4699600 | cell-based format | Scientific Literature | |
17. | ALA4704567 | ADME | Cytotoxicity against human U-87 MG cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 5 | ALA4699600 | cell-based format | Scientific Literature | |
18. | ALA4704568 | ADME | Cytotoxicity against human A172 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 5 | ALA4699600 | cell-based format | Scientific Literature | |
19. | ALA4704569 | ADME | Cytotoxicity against human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 5 | ALA4699600 | cell-based format | Scientific Literature | |
20. | ALA4704570 | Functional | Induction of apoptosis in human U87MG cells assessed as necrotic cells at 10 uM incubated for 48 hrs by Annexin-V/propidium iodide staining based flow cytometric method (Rvb = 0.43 %) | Homo sapiens | 5 | ALA4699600 | cell-based format | Scientific Literature |