| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4688262 | B | Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated for 1 hr followed by fluorogenic probe addition and measured after 3 hrs by HTRF assay | Homo sapiens | 36 | assay format | Scientific Literature | ||
| 2. | ALA4688263 | B | Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by quanti-blue based SEAP assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 3. | ALA4688264 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 10 mins | Homo sapiens | 34 | microsome format | Scientific Literature | ||
| 4. | ALA4688265 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining after 10 mins | Mus musculus | 34 | microsome format | Scientific Literature | ||
| 5. | ALA4688266 | A | Inhibition of recombinant CYP2C9 (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 6. | ALA4688267 | A | Inhibition of recombinant CYP2C19 (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 7. | ALA4688268 | B | Inhibition of human recombinant His-tagged TNF-alpha-mediated E-selectin expression in HUVEC cells preincubated for 30 mins in presence of TNFalpha and measured after 3 hrs by flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4688269 | A | Metabolic stability in human liver microsomes assessed as half-life | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 9. | ALA4688270 | A | Metabolic stability in rat liver microsomes assessed as half-life | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 10. | ALA4688271 | A | Metabolic stability in mouse liver microsomes assessed as half-life | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 11. | ALA4688272 | A | Permeability of the compound across apical to basolateral side of membrane in human Caco-2 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4688273 | A | Permeability of the compound across basolateral to apical side of membrane in human Caco-2 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4688274 | A | Inhibition of recombinant CYP1A2 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4688275 | A | Inhibition of recombinant CYP2C8 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4688276 | A | Inhibition of recombinant CYP2D6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4688277 | A | Inhibition of recombinant CYP3A4 (unknown origin) in presence of BFC as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4688278 | A | Protein binding in human assessed as unbound fraction | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4688279 | A | Protein binding in rat assessed as unbound fraction | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 19. | ALA4688280 | A | Protein binding in mouse assessed as unbound fraction | Mus musculus | 1 | assay format | Scientific Literature | ||
| 20. | ALA4688281 | P | Solubility of compound | 1 | small-molecule physicochemical format | Scientific Literature |
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