# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4775527 | Binding | Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay | Homo sapiens | 28 | ALA4765480 | single protein format | Scientific Literature | |
2. | ALA4775528 | Binding | Inhibition of TYK2 in IFN-alpha stimulated human Kit225 T cells by luciferase reporter gene assay | Homo sapiens | 28 | ALA4765480 | tissue-based format | Scientific Literature | |
3. | ALA4775529 | Binding | Inhibition of TYK2 in human whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylation | Homo sapiens | 28 | ALA4765480 | tissue-based format | Scientific Literature | |
4. | ALA4775534 | ADME | Permeability from apical to basolateral side in human Caco-2 cells | Homo sapiens | 23 | ALA4765480 | cell-based format | Scientific Literature | |
5. | ALA4775535 | ADME | Cmax in mouse at 10 mg/kg, po | Mus musculus | 4 | ALA4765480 | organism-based format | Scientific Literature | |
6. | ALA4775536 | ADME | AUC (0 to 24 hrs) in mouse at 10 mg/kg, po | Mus musculus | 4 | ALA4765480 | organism-based format | Scientific Literature | |
7. | ALA4775537 | ADME | Clearance in mouse at 10 mg/kg, po | Mus musculus | 4 | ALA4765480 | organism-based format | Scientific Literature | |
8. | ALA4775538 | ADME | Volume of distribution at steady state in mouse at 10 mg/kg, po | Mus musculus | 4 | ALA4765480 | organism-based format | Scientific Literature | |
9. | ALA4775539 | ADME | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 4 | ALA4765480 | organism-based format | Scientific Literature |