| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4680527 | B | Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 2. | ALA4680529 | B | Inhibition of human peYFP-C1 TRPV6 expressed in HEK293 cells assessed as decrease in whole cell calcium current at 0.1 uM at 50 mV holding potential in presence of La3+ by patch clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4680530 | B | Inhibition of human peYFP-C1 TRPV6 expressed in HEK293 cells assessed as decrease in whole cell calcium current at 10 uM at 50 mV holding potential in presence of La3+ by patch clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4680531 | B | Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx at 10 uM preincubated with compound followed by Cdcl2 addition measured for 12 to 30 mins by Leadmium-green and Alexafluor-594 conjugate based confocal microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4680532 | F | Effect on cadmium induced toxicity in wild type human HEK293 cells assessed as cell survival at 1 to 10 uM incubated for 24 hrs by XTT assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA4680533 | B | Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in cadmium induced cytotoxicity by measuring increase in cell survival at 10 uM incubated for 24 hrs by XTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4680534 | U | Selectivity index, ratio of IC50 for human TRPV5 expressed in HEK293 cells to IC50 for human TRPV6 expressed in HEK293 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4680535 | A | Inhibition of rat L-type calcium channel (diltiazem site) at 10 uM | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 9. | ALA4680536 | A | Inhibition of SOCE in human MDA-MB-231 cells at 5 uM pretreated for 20 mins followed by Tg addition for 10 mins followed by CaCl2 addition by FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4680537 | A | Activation of human TRPV1 expressed in HEK293T cells preincubated for 5 mins followed by CaCl2 addition by calcium-5 fluorescence dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4680538 | A | Inhibition of human TRPV1 expressed in HEK293T cells preincubated for 5 mins followed by CaCl2 addition by calcium-5 fluorescence dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4680539 | B | Inhibition of human ERG at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA4680540 | A | Stability in human liver microsomes assessed as half life | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 14. | ALA4680541 | A | Antiproliferative activity against human T47D cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4680542 | A | Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4680543 | A | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4680544 | A | Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4680545 | A | Antiproliferative activity against wild type human HEK293 cells assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4680546 | A | Antiproliferative activity human HEK293 cells expressing human TRPV6 assessed as cell growth inhibition at 0.4 to 100 uM after 6 days by XTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4680547 | A | Cytotoxicity against human T47D cells assessed as induction of cell morphological changes at 100 uM by inverted microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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