# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4669329 | F | Induction of NK-mediated antitumor immunity in ip dosed C57BL/6 mouse xenografted with human Lewis lung carcinoma cells assessed as increase in NK cell infiltration in tumor by immunofluorescent staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
2. | ALA4669330 | F | Antitumor activity against human Lewis lung carcinoma cells xenografted in ip dosed C57BL/6 mouse assessed as reduction in tumor weight administered for 20 consecutive days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
3. | ALA4669331 | F | Antitumor activity against human Lewis lung carcinoma cells xenografted in ip dosed C57BL/6 mouse assessed as reduction in tumor volume administered for 20 consecutive days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
4. | ALA4669332 | B | Inhibition of TGF-beta induced SMAD2 phosphorylation in human A549 cells at 5 to 10 uM pretreated with compound for 2 hrs followed by TGF-beta stimulation by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4669333 | B | Inhibition of TGF-beta induced SMAD3 phosphorylation in human A549 cells at 5 to 10 uM pretreated with compound for 2 hrs followed by TGF-beta stimulation by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4669335 | P | Solubility of the compound in PBS buffer at pH 7.4 | 2 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4669336 | F | Cytotoxicity against human A549 cells assessed as inhibition of cell growth by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4669337 | B | Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase by CAGA-based luciferase reporter assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4669338 | B | Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase at 10 uM by CAGA-based luciferase reporter assay relative to control | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
10. | ALA4669339 | B | Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase at 5 uM by CAGA-based luciferase reporter assay relative to control | Homo sapiens | 26 | cell-based format | Scientific Literature |