# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4768579 | Functional | Cell cycle arrest in human COLO 205 cells assessed as accumulation at G0/G1 phase at 200 nM measured after 24 hrs by propidium iodide staining based flow cytometry relative to control | Homo sapiens | 4 | ALA4765279 | cell-based format | Scientific Literature | |
2. | ALA4768580 | Binding | Selectivity ratio of IC50 for inhibition of CDK9/cyclin T1 (unknown origin) to IC50 for inhibition of recombinant human full-length N-terminal GST-fused CDK4 (1 to 303 residues)/GST-tagged CyclinD3 (1 to 292 residues) expressed in baculovirus expression system | Homo sapiens | 3 | ALA4765279 | assay format | Scientific Literature | |
3. | ALA4768581 | Binding | Selectivity ratio of IC50 for inhibition of CDK2/cyclin A2 (unknown origin) to IC50 for inhibition of recombinant human full-length N-terminal GST-fused CDK4 (1 to 303 residues)/GST-tagged CyclinD3 (1 to 292 residues) expressed in baculovirus expression system | Homo sapiens | 3 | ALA4765279 | assay format | Scientific Literature | |
4. | ALA4768582 | Binding | Inhibition of CDK9/cyclin T1 (unknown origin) | Homo sapiens | 4 | ALA4765279 | protein complex format | Scientific Literature | |
5. | ALA4768583 | Binding | Inhibition of recombinant human full-length N-terminal GST-fused CDK4 (1 to 303 residues)/GST-tagged CyclinD3 (1 to 292 residues) expressed in baculovirus expression system using ULight-elF4E-binding protein 1 peptide as substrate measured after 30 mins by LANCE assay | Homo sapiens | 26 | ALA4765279 | assay format | Scientific Literature | |
6. | ALA4768584 | Binding | Inhibition of human full-length N-terminal GST tagged CDK6 (1 to 326 residues)/GST-tagged cyclinD3 (1 to 292 residues) expressed in baculovirus expression system using ULight-elF4E-binding protein 1 peptide as substrate measured after 30 mins by LANCE assay | Homo sapiens | 26 | ALA4765279 | assay format | Scientific Literature | |
7. | ALA4768585 | Functional | Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay | Homo sapiens | 20 | ALA4765279 | cell-based format | Scientific Literature | |
8. | ALA4768586 | Functional | Antiproliferative activity against human U-87 MG cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay | Homo sapiens | 20 | ALA4765279 | cell-based format | Scientific Literature | |
9. | ALA4768587 | Functional | Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 to 6 days by celltiter-glo luminescent cell viability assay | Homo sapiens | 4 | ALA4765279 | cell-based format | Scientific Literature | |
10. | ALA4768588 | ADME | Intrinsic clearance in human liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 1 hr by LC-MS/MS analysis | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
11. | ALA4768589 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition and measured after 1 hr by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4765279 | microsome format | Scientific Literature | |
12. | ALA4768590 | ADME | Inhibition of CYP1A2 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
13. | ALA4768591 | ADME | Inhibition of CYP2C9 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
14. | ALA4768592 | ADME | Inhibition of CYP2C19 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
15. | ALA4768593 | ADME | Inhibition of CYP2D6 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
16. | ALA4768594 | ADME | Inhibition of CYP3A4 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
17. | ALA4768595 | ADME | Time-dependent inhibition of CYP1A2 in human liver microsomes at 10 uM in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
18. | ALA4768596 | ADME | Time-dependent inhibition of CYP2C9 in human liver microsomes at 10 uM in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
19. | ALA4768597 | ADME | Time-dependent inhibition of CYP2C19 in human liver microsomes at 10 uM in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature | |
20. | ALA4768598 | ADME | Time-dependent inhibition of CYP2D6 in human liver microsomes at 10 uM in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | ALA4765279 | microsome format | Scientific Literature |