# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4701302 | B | Inhibition of N-terminal FLAG-tagged and C-terminal strep-tagged human PARP10 (805 to 1025 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay | Homo sapiens | 3 | ALA4699460 | cell-based format | Scientific Literature | |
2. | ALA4701303 | B | Inhibition of N-terminal FLAG-tagged and C-terminal strep-tagged human PARP10 (805 to 1025 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 1 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay | Homo sapiens | 10 | ALA4699460 | cell-based format | Scientific Literature | |
3. | ALA4701304 | B | Inhibition of N-terminal FLAG-tagged and C-terminal strep-tagged human PARP10 (805 to 1025 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 10 | ALA4699460 | cell-based format | Scientific Literature | |
4. | ALA4701305 | B | Inhibition of N-terminal His-GST tagged human PARP14 (1470 to 1801 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 1 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 10 | ALA4699460 | cell-based format | Scientific Literature | |
5. | ALA4701306 | B | Inhibition of N-terminal GST tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature | |
6. | ALA4701307 | B | Inhibition of N-terminal GST tagged full length human PARP3 expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature | |
7. | ALA4701308 | B | Inhibition of N-terminal GST tagged full length human PARP6 expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature | |
8. | ALA4701309 | B | Inhibition of N-terminal FLAG-tagged human PARP7 (400 to 657 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature | |
9. | ALA4701310 | B | Inhibition of PARP8 (unknown origin) assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | single protein format | Scientific Literature | |
10. | ALA4701311 | B | Inhibition of N-terminal GST tagged human PARP11 (8 to 338 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature | |
11. | ALA4701312 | B | Inhibition of N-terminal His-GST tagged human PARP12 (500 to 701 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature | |
12. | ALA4701313 | B | Inhibition of N-terminal GST-tagged human PARP15 (221 to 444 residues) expressed in Escherichia coli assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | assay format | Scientific Literature | |
13. | ALA4701314 | B | Inhibition of N-terminal GST-tagged human TNKS1 (1001 to 1327 residues) expressed in baculovirus-infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature | |
14. | ALA4701315 | B | Inhibition of TNKS2 (unknown origin) at 10 uM relative to control | Homo sapiens | 2 | ALA4699460 | single protein format | Scientific Literature | |
15. | ALA4701317 | B | Inhibition of N-terminal GST tagged human PARP1 (2 to 1041 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in NAD+-dependent ADP ribosylation using histone as substrate at 10 uM incubated for 1 hr in presence of biotinylated NAD+ and activated DNA by chemiluminescence based microplate reader assay relative to control | Homo sapiens | 2 | ALA4699460 | cell-based format | Scientific Literature |