| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4669220 | Binding | Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay | Homo sapiens | 28 | ALA4665717 | cell-based format | Scientific Literature | |
| 2. | ALA4669222 | Functional | Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay | Homo sapiens | 20 | ALA4665717 | cell-based format | Scientific Literature | |
| 3. | ALA4669223 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Homo sapiens | 20 | ALA4665717 | microsome format | Scientific Literature | |
| 4. | ALA4669224 | ADME | Metabolic stability in Wistar rat liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Rattus norvegicus | 20 | ALA4665717 | microsome format | Scientific Literature | |
| 5. | ALA4669225 | ADME | Metabolic stability in NMRI mouse liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Mus musculus | 20 | ALA4665717 | microsome format | Scientific Literature | |
| 6. | ALA4669226 | ADME | Apparent permeability across apical to basolateral side in vinblastine-treated human Caco-2 cells at 1 uM by HPLC-UV analysis | Homo sapiens | 4 | ALA4665717 | tissue-based format | Scientific Literature | |
| 7. | ALA4669228 | ADME | Efflux ratio of Apparent permeability across apical to basolateral side in vinblastine-treated human Caco-2 cells expressing P-glycoprotein at 1 uM by HPLC-UV analysis | Homo sapiens | 4 | ALA4665717 | tissue-based format | Scientific Literature | |
| 8. | ALA5247258 | ADME | Apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 5 | ALA5244278 | cell-based format | Scientific Literature | |
| 9. | ALA5247305 | Binding | Antagonist activity against human V1A receptor expressed in human 1321N1 cells | Homo sapiens | 4 | ALA5244278 | cell-based format | Scientific Literature | |
| 10. | ALA5247306 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 4 | ALA5244278 | microsome format | Scientific Literature | |
| 11. | ALA5247307 | ADME | Metabolic stability in rat liver microsomes assessed as intrinsic clearance | Rattus norvegicus | 4 | ALA5244278 | microsome format | Scientific Literature | |
| 12. | ALA5247308 | ADME | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 4 | ALA5244278 | microsome format | Scientific Literature | |
| 13. | ALA5247309 | ADME | Efflux ratio of apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 3 | ALA5244278 | cell-based format | Scientific Literature | |
| 14. | ALA5247310 | Physicochemical | Kinetic solubility of the compound at pH 7.4 | 4 | ALA5244278 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!