| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4716830 | B | Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-Glo luciferase assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 2. | ALA4716832 | B | Inhibition of Tel fused InsR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-Glo luciferase assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 3. | ALA4716833 | A | Antiproliferative activity against wild type mouse BaF3 cells assessed as reduction in cell growth incubated for 2 to 3 days by Bright-Glo luciferase assay | Mus musculus | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA4716862 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 4 | microsome format | Scientific Literature | ||
| 5. | ALA4716863 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 6. | ALA4716864 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 7. | ALA4716865 | A | Inhibition of CYP3A4 (unknown origin) using midazolam as substrate | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA4716866 | P | Solubility in DMSO at pH 6.8 by high-throughput solubility assay | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4716867 | A | Permeability of compound by PAMPA assay | 4 | assay format | Scientific Literature | |||
| 10. | ALA4716868 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4716870 | A | Efflux ratio of permeability across basolateral to apical side over apical to basolateral side in human Caco2 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4716871 | B | Inhibition of human ERG by dofetilide binding assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA4716872 | A | Clearance in mouse at 5 mg/kg, iv | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA4716873 | A | Volume of distribution at steady state in mouse at 5 mg/kg, iv | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA4716874 | A | Cmax in mouse at 20 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA4716875 | A | AUC in mouse at 20 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4716876 | A | Oral bioavailability in mouse at 20 mg/kg | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4716887 | B | Selectivity ratio of IC50 for NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation to IC50 for Tel fused InsR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation | 10 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!