| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4724695 | B | Inhibition of NanoLuc-tagged VHL in HEK293 cells incubated for 2 hrs by NanoBRET live cell assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4724696 | B | Inhibition of recombinant human GST-tagged ERK5 (1 to 398 assessed as phosphorylated peptide substrate incubated for 60 mins by TR-FRET based biochemical assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA4724697 | P | Solubility of compound in PBS buffer at pH 6.5 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4724698 | P | Lipophilicity, logD of compound at pH 7.5 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4724699 | A | Permeability of compound by PAMPA-BBB assay | 1 | assay format | Scientific Literature | |||
| 6. | ALA4724700 | B | Inhibition of VHL (unknown origin) assessed as phosphorylated peptide substrate incubated for 60 mins by TR-FRET based biochemical assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4724701 | B | Ratio of IC50 for protac activity at NanoLuc-tagged VHL/ERK5 in HEK293 cells assessed as inhibition of VHL activity incubated for 2 hrs by NanoBRET live cell assay to IC50 for protac activity at VHL/ERK5 (unknown origin) assessed as inhibition of VHK activity by measuring phosphorylated | Homo sapiens | 1 | cell-based format | Scientific Literature |
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